Tuesday, February 2, 2010

Call to end exclusion of elderly from drug trials

This news story caught my eye because I have become concerned about this very issue over the past six or seven years. In my way of thinking it is important to set up specific drug trials not just for Elders but for children and women too.

In 2003 my mother suffered a closed head injury, and as a result of her fall and the TBI she developed expressive aphasia.

Expressive aphasia is condition  and an acquired disorder of language due to brain damage. Most aphasias and related disorders are due to stroke, head injury, cerebral tumors, or degenerative diseases.  People may lose the ability to produce speech, to comprehend speech, to repeat, and to hear and read words in many nuanced ways. Language difficulties can also be affected by pharmaceutical drugs often over used in faculties that care for Elders.

Speech and language therapy is the mainstay of care for people with with aphasia. The timing and nature of the interventions for aphasia vary widely. Blinded studies are limited, and recovery of many degrees is expected.  Studies also indicate that speech and language therapy does improve clinical outcomes in aphasia, but individualized programs are important. 

The potential for functional recovery from primarily expressive aphasia after stroke is excellent. A neurologist should be key in evaluation and care, as well as speech therapy.

After her injury, my mother was placed in a 5 Star facility in Naples, Florida.  She was loaded up with an over abundance of psychotropic drugs, including  Zyprexa, yet did not have a neurologist or speech therapy prescribed.

Zyprexa is questionable for the elderly, especially for use in elderly women, and it can precipitate diabetes.  The case in point is that regardless of the number of drugs prescribed, and failure of the center to evaluate the drugs for interaction, no one except me questioned the use of this drug in my mother's care.  Zyprexa has an unusually difficult time being excreted by older women and as a result has a longer half-life.

Another drug being given to my mother, not prescribed by a neurologist, was Neurontin, and it is implicated in the development of impaired speech. And yet another one of the several SSRIs perscribed has a known side effect of suicidal thinking.  My mother tried to jump out of a window.  The outcome: more drugs to sedate her further.

The house psychiatrist diagnosed my mother as depressed.  Yet when I asked how he diagnosed her with the aphasia, he could not answer.  He just prescribed more drugs.

I contacted a colleague in the pharmaceutical research section dealing with psychotropic durgs at the FDA for an opinion on the list of drugs prescribed to my mother.  He was shocked, and especially noted the severe issues indicated by the drug interaction profile.

The care center supplying pharmacy never conducted a thorough interaction profile. 
The attending GP, a whining DO from a near by town, most likely interested in the Medicare reimbursement more than my mother's condition, whined to my brother after I talked with him, saying he did not like the questions I was asking.

The director of nursing threatened forced relocation if my mother was taken off any of the drugs.  Since the bill went to Medicare I am sure reimbursement was more the concern than my mother's well being.  And of course there is the issue of staff convenience.

Well, my mother died last summer.  She won't be forced now to take any more drugs, but for six years which must have been agonizing for her, she was over drugged and could not communicate.

My little brother, who held POA, a player in the insurance/finance business, made absolutely no effort to see that my mother was taken to a nationally recognized neurologist in Naples.  Nor would acknowledge my concerns over the drugs and her treatment.  He failed to get her even the most clearly established care for  the aphasia, but was concerned over the cost of the drugs.

He also failed to tell the care center that my mother had a daughter, and didn't make any effort to contact me about this incident until three months after it happened.
Read the complete areticle here - http://news.bbc.co.uk/2/hi/health/8487509.stm

Matters of the Heart

Yes, it is heart month and with that comes the latest attack on herbal remedies at the behest of Big PhRMA, CNN, and Time-Warner's medical mainstream Health.com.
While the ABC was contacted and interviewed for the article, nothing was given to provide the risks of the anticoagulant warfarin or statin drugs used as examples in the article.
Health.com lists 20 herbs in their article and I will follow up with my comments on the drugs and the benefits of their 20 selected herbs.
Included in the list is garlic.  And of course you know that CNN's own Larry King uses a garlic supplement for his heart condition, and has advertised it for years.Garlic is one of the best herbs for blood thinning as well as being an excellent source of magnesium to help keep blood pressure levels down.
Stay tuned...
And now - here's that retort to CNN and Health.com
Natural Health News: Continuing the Attack on Natural Health Care
By Gayle Eversole, Dhom, PhD, MH, NP, ND
www.leaflady.org, and rense.com

Today, CNN and Time-Warner's Health.com published articles warning you to avoid 30 herbs if you are taking drugs like the allegedly cholesterol lowering statins and “blood-thinning” Coumadin (warfarin). http://www.health.com/health/gallery/0,,20340370_20,00.html

As an inveterate and intrepid nurse practitioner (over 30 years), medical herbalist and otherwise expert and advocate in natural health (50+ years), I am staking my claim to equal time and offering a second opinion.

Statin drugs by and large are a class of very expensive drugs with a range of mixed results. The very serious effects of these drugs include liver failure, sudden cardiac death, increased risk of cancer, kidney failure, destruction of CO-Enzyme Q 10 and specific B vitamins needed by the heart, muscle pain and destruction, as well as being questionable over all because they appear not to serve the purpose described in the advertising according to many recent studies.

There are many natural approaches to lowering cholesterol including changes in diet and exercise, as well as making sure your thyroid is functioning properly.

One common supplement to help lower cholesterol is lecithin. Health.com' s expert Bill Benda MD says he has no knowledge of the benefit of lecithin yet suggests using red rice yeast. Red Rice Yeast is LOVASTATIN and has the same risk of rhabdomyolysis leading to kidney failure as do the Rx strength drugs.

Each tablespoon (7.5 grams) of lecithin granules contains about 1700 mg of phosphatidyl choline, 1000 mg of phosphatidyl inositol, and about 2,200 mg of essential fatty acids as linoleic acid. It also contains the valuable omega-3 linolenic acid. These constituents should be supllied daily.
Rinse, Jacobus (1975) Atherosclerosis: prevention and cure (parts 1 and 2). Prevention. November and December. Very important reading. Ask your librarian to get you these specific issues (or photocopies) through inter-library loan.
Rinse, Jacobus (1978) Cholesterol and phospholipids in relation to atherosclerosis. American Laboratory Magazine, April.
Glabridin shows a significant 10 percent drop in LDL cholesterol levels. These studies show a 20 percent reduction in oxidized LDL cholesterol and measures of oxidative stress, well-known risks for development of atherosclerosis. No change in these predictive markers, was seen in the placebo group.1
Glabridin is a powerful polyphenol flavonoid derived from Glycyrrhiza glabra L root (licorice). Animal studies have revealed that daily doses of glabridin can suppress abdominal fat accumulation and blood sugar elevation in diabetic mice, while human trials show that it can reduce weight gain and body fat—especially visceral or belly fat. And according to another recently published clinical trial, this botanical extract packs the same punch against LDL cholesterol, too.
1 Carmeli E, Fogelman Y. Antioxidant effect of polyphenolic glabridin on LDL oxidation. Toxicol Ind Health. 2009 May-Jun;25(4-5):321-4.
Herbs and foods included in the report that help thin the blood naturally include: Garlic, saw palmetto, ginkgo, green tea, alfalfa, ginger, bilberry, fenugreek, ginseng, Butcher's Broom and capsicum (cayenne).

The report did not explain that long term use of aspirin or warfarin increases the risk of silent bleeding, ulcers and the severe risk of destruction of the cell wall membrane and clotting disorders.

Statins, beta-blockers, and calcium-channel blockers can be effected by St. John's wort, Echinacea, grapefruit juice, and Black Cohosh. But remember that statins come with the risk of liver damage. Calcium channel blockers can cause sudden death at one point were almost taken off the market because of the risk. Beta blockers have come into question for safety and efficacy in recent years.

Hawthorn has been shown to strengthen the contractions of heart muscle, which may interact negatively with prescription heart-failure medications. Hawthorn has always been a first line of defense for heart health in herbal medicine. I have worked with many people who lived with heart health issues. I've always found Hawthorn to be a key factor in their improved quality of life.

Night blooming cereus and Lily of the Valley may also be an experienced herbalist' s choice for cardiovascular care.

Yohimbe can elevate blood pressure and at times and for some people this would be helpful, but in general it is not one I often suggest.

Aloe vera can effect potassium levels. Licorice can interfere with digoxin and it can raise blood pressure. Like aloe vera, it can also cause a dangerous drop in blood potassium levels.

Other herbs in the study mentioned in this report include Butcher's broom, angelica, capsicum (cayenne), fumitory, gossypol, Irish moss, kelp, khella, lily of the valley, ephedra, night-blooming cereus (cactus flower), oleander, and strophanthus can all interact negatively with heart medications.

Health care is your choice. Natural remedies like herbs and supplements can do an effective job helping you heal when you do not wish to choose or cannot tolerate prescription drugs.

Because doctor's work for you, the question must be asked: When will today's medicine and today's doctors meet you half way and support natural choice?

Always stay in communication with your health provider and contact an experienced herbalist or naturally oriented doctor for additional resources.
Reinforcements from the field

ABC Responds to Article on Herb-Drug Interactions in Journal of the American College of Cardiology
2010/02/03 - American Botanical Council


Article should be retracted and corrected says herbal science group

(Austin, TX) February 2, 2010. At least several times per year an article is published in a medical journal that purports to provide health professionals and the public with useful information on the safety of herbs and herbal dietary supplements. Instead, what sometimes occurs is an article written by people with apparently little to no expertise in the subject area of herbal medicine and medicinal plant research and likewise apparently peer reviewed—if peer reviewed at all—by reviewers with little botanical knowledge or expertise. Yesterday, the Journal of the American College of Cardiology published such an article.1
This particular article has so many flaws and errors that it is difficult to know where to begin to critically review it.

First, Latin names for the herbs discussed are missing, a disservice to any readers who may not be familiar with common names used in the United States.

Second, some of the tables in the article contain entries for “commonly used herbs,” which include the toxic plant oleander (Nerium oleander, a toxic herb with cardioactive glycosides not sold to consumers in the US dietary supplement market); chan su (presumably dried Chinese toad venom—not an herb nor generally available as a dietary supplement!); and Uzara root (Xysmalobium undulatum, an anti-diarrhea herbal drug approved in Germany.) None of these are “commonly” found in the US herbal dietary supplement market.

Grapefruit juice, which is well known for increasing serum levels of many pharmaceutical drugs, is referred to as an herb.

The authors refer to “ginseng” without clarifying to which species of the genus Panax they are referring, many of which cause varying pharmacological effects. Also, with respect to ginseng, the authors unfortunately repeat the highly erroneous adverse effect information from the widely discredited 1979 uncontrolled study by RK Siegel on the “Ginseng Abuse Syndrome,” stating that “ginseng” can cause “hypertension, behavioral changes and diarrhea.”

Capsicum is listed in a table as being used for shingles, trigeminal, and diabetic neuralgia, when it is actually the US Food and Drug Administration-approved over-the-counter and prescription drug capsaicin, the vanillanoid compound derived from chili peppers (Capsicum spp.), which is used for such purposes.

There are more; the errors and problems in this paper are too numerous to list completely at this time.

While there are potential and actual interactions that various herbs can have with drugs used by patients with cardiovascular diseases, this paper will do little to improve professional awareness and skill in this area. However, the resulting media coverage will undoubtedly increase public confusion over what is an already confused subject. This paper should not have been published in its present form without serious additional edits, revisions, and deletions, and the Journal of the American College of Cardiology would be advised to retract it.

Reference

Tachjian A, Maria V, Jahangir A. Use of herbal products and potential interactions in patients with cardiovascular diseases. J Amer Coll Cardiol. 2010;55(6). [DOI:10.1016/j.jacc.2009.07.074].

About the American Botanical Council

Founded in 1988, the American Botanical Council is a leading international nonprofit organization addressing research and educational issues regarding herbs and medicinal plants. ABC’s members include academic researchers and educators; libraries; health professionals and medical institutions; government agencies; members of the herb, dietary supplement, cosmetic, and pharmaceutical industries; journalists; consumers; and others within over 70 countries. The organization occupies a historic 2.5-acre site in Austin, Texas where it publishes the quarterly journalHerbalGram, the monthly e-publication HerbalEGram, HerbClips (summaries of scientific and clinical publications), reference books, and other educational materials. ABC also hosts HerbMedPro, a powerful herbal database, covering scientific and clinical publications on more than 220 herbs. ABC also co-produces the “Herbal Insights” segment for Healing Quest, a television series on PBS.

ABC is tax-exempt under section 501(c) (3) of the IRS Code. Information: Contact ABC at P.O. Box 144345, Austin, TX 78714-4345, Phone: 512-926-4900. Website: http://www.herbalgram.org/.


Supermarket fridges polluting with fluoride containing hydrocarbons

Supermarket fridges as polluting as their plastic bags, study claims

The switch to refrigerants that do not damage the ozone layer brought in a generation of chemicals with a greenhouse effect thousands of times stronger than CO2

"The environmental impact of supermarket refrigeration is a big issue but little understood … it is a hell of a lot bigger than free plastic bags."
The EIA is concerned about the widespread use of damaging HFC (hydrofluorocarbon) gases as coolants. Supermarkets are the biggest industrial emitters of HFCs, which were hurriedly introduced in the 1990s as a safer alternative to ozone-depleting chemicals such as CFCs (chlorofluorocarbons) and hydrochlorofluorocarbons (HCFCs).

HFCs do not damage the ozone layer but their global warming potential is ­significant. One tonne of the widely used gas called R404a has a warming effect equal to 3,900 tonnes of CO2 over a 100-year period. The level of leakage of the chemicals is equivalent to 1bn car journeys to the average local super­market. The gases escape in normal use and maintenance.

Antidepressants, Plainly Depressing

Since I started once again on the fluoride issue here is a first follow up - there are a few more coming your way.

"The Depressing News About Antidepressants" is a topic frequently discussed on Natural Health News, and the title of  a recent Newsweek article.

Perusing NHN you'll find about 30+ articles focusing on depression and antidepressant drugs.  Most of the newer ones are the fluoride based SSRIs which had created a world of problems all their own.

If you travel back in time about two years ago you'll find this discussion http://naturalhealthnews.blogspot.com/2008/11/no-difference-in-psych-drugs-for.html

I guess I wonder why nothing has come about to address the serious issues with these drugs, especially in light of the latest re-coverage of fish oil, other vitamins, and nutrition for mental health care.  Perhaps if we drop the drugs we can eliminate high school shootings in the future and better mental health care.

Here's one champion of natural psychiatry, with no offense to my long-ago friend Bill Greenberg MD at Beth Israel/Harvard.

You might be pleased to know that Dr Bloem just prevailed against the MD medical board who attempted to punish her for using other than the standard SSRI and similar mainstream status quo therapy.

The Safe Harbor Project has too been a long time advocate for natural mental health.

If you have a difficult ime understanding dangerous fluoride, here's help

" In the face of overwhelming data proving that fluoride is not only not beneficial but extremely harmful; the reliable evidence that the government has known of this for over sixty years..."

http://www.apfn.org/THEWINDS/archive/medical/fluoride01-98.html

5 ways to bust through a fat loss plateau!

Ever hit a "wall" in your fat loss program where your progress just seemed to come to a schreeching halt?

Perhaps you're experiencing it now...

Well, good news -- scratch that, GREAT news.

Fitness model and author John Romaniello is offering a complimentary download of his new fat loss report "Why You've STOPPED Losing Body Fat...And How to Fix It" over at his website.

The download is totally FREE:

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John really went over the top here -- more than 25 pages of pure, actionable content that will absolutely help you immediately begin losing fat FASTER.

Here's the link again:

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Enjoy the report!

Arthur M.

P.S. There are no "strings" here. Just tap on the link above and you'll be downloading the report before you know it.

Monday, February 1, 2010

1 "Weird" Workout Program

I've never tried a workout like this before...but I just reviewed the new Turbulence Training Adrenaline Circuit Workout and it looks so cool!

You'll agree though, that it's also kind of weird.

I mean NO other trainer is using intervals in this set-up, but Craig actually explains WHY you are doing them that way. If you're into the science behind workouts, you'll love his Adrenaline Intervals article.

(Of course, 95% of trainers out there don't have a clue about the science of fat loss - but with Turbulence Training Adrenaline, you'll get shown scientific PROOF that this program works.)

Turbulence Training is the ONLY choice for smart workouts that are proven, FUN, and guaranteed to get results.

And if this is the year that you're finally going to get the results you deserve, than you need the complete "4 for 1" Turbulence Training package that is on sale this week.

For beginners, you'll start with the TT Beginner Total Torso Training program, and then graduate to TT 2K10, then to TT Transformation, and finally to TT Adrenaline.

And if you're advanced and want the Ultimate Challenge, you can go directly to TT Adrenaline. Do that circuit challenge, and post your results on the TT Member's Forum.

Just say NO to cardio, and YES to results with Turbulence Training.

But hurry, the TT "4 for 1" offer ends on Wednesday, February 3rd.

On that day, the January workouts will be pulled from the offer.

But until then, you will get immediate access to all three January TT Workouts PLUS the new TT Adrenaline program for the price of one workout (only $19.95).

So it's now "4 for 1".

Oh, and the TT Kettlebell 15-Minute Express workout will be ready soon too! (So make that "5 for 1"!)

PLUS you'll also get 30 days free in the TT Member's area where you can ask Craig all of your training and nutrition questions

The total value of all of these workouts and bonuses is well over $119, but you can get this Complete TT 2K10 Package for only $19.95 today.

Click here to get started with this amazing fat burning deal:

=> http://bit.ly/9ZGIBq

But hurry, because this is your LAST CHANCE to get all of these workouts and bonuses for such a low investment before they get put back in the TT Member's Platinum Vault.

To Your Success,

Arthur M.

http://bit.ly/9ZGIBq

PS - Don't forget, you will also receive...

...30 days access to the TT Member's area and forum where you can ask Craig ALL of your training and nutrition questions.

Craig watches that forum like a HAWK, checking in every few hours to make sure all questions get answered and new members get welcomed.

So make sure to take advantage of his help and the complete social support system from all other TT Members.

PPS - Get ready for TT Adrenaline...

...this is a new scientifically-formulated workout program unlike any other Turbulence Training workout Craig has ever designed...

...Click here to get access to the workouts IMMEDIATELY:

=> http://bit.ly/9ZGIBq

NOTE: This promotion ends on Wednesday, February 3rd, and then these three workouts will be removed and locked up in the TT Platinum Member's Vault.

PPPS - Your results are guaranteed by Craig's 100% money back promise. If you aren't COMPLETELY satisfied with your results from the TT programs, just let Craig know and you'll be refunded your $19.95 before the end of the 30-day member period and you won't be billed any additional charges.

And no matter what, you'll get to keep ALL of the workouts!

[Note: This posting is intended to make you aware of the availability of this program and offer. It’s not a personal endorsement! As always please note the Compensated Affiliate Disclosure at the sidebar!]