Showing posts with label osteoporosis. Show all posts
Showing posts with label osteoporosis. Show all posts

Thursday, June 3, 2010

New Drug, New Risk

 Today it was announced that the FDA approved this new genetically engineered drug for osteoporosis.  AMGEN is certainly looking forward to it being a "blockbuster" and generator for big profit.

My hope is that it is a wake-up to women who need to have much better information about what they can do to prevent and treat bone loss issues in a more natural and nutritional way.

Vitamin D is certainly important, some use of calcium supplementation (natural sources are better like horsetail, nettle, etc), better overall nutritional support, avoiding calcium-depleting soy, weight bearing exercise, adequate hydration, and customized natural care.
Denosumab is known to cause significant suppression of bone turnover and this suppression may contribute to the occurrence of osteonecrosis of the jaw, a factor that raised concern at an FDA advisory panel last August.

Other common side effects reported with denosumab include back pain, pain in the extremities, musculoskeletal pain, high cholesterol levels, and urinary bladder infections.

Serious adverse reactions include hypocalcemia, serious infections, including infections of the skin, and dermatologic reactions such as dermatitis, rashes, and eczema. from MedPage Today

Immune suppression for osteoporosis?  one of 32 posts regarding osteoporosis found on Natural Health News
Prolia application info

http://www.medpagetoday.com/Endocrinology/Osteoporosis/20432?utm_content=GroupCL&utm_medium=email&impressionId=1275544771411&utm_campaign=DailyHeadlines&utm_source=mSpoke&userid=68851

Friday, October 2, 2009

Osteoporosis drug Forteo linked with bone cancer

BLACK BOX WARNING FOR FORTEO, a gentically engineered pharmaceutical
POTENTIAL RISK OF OSTEOSARCOMA: In male and female rats, teriparatide caused an increase in the incidence of osteosarcoma (a malignant bone tumor) that was dependent on dose and treatment duration. The effect was observed at systemic exposures to teriparatide ranging from 3 to 60 times the exposure in humans given a 20-mcg dose. Because of the uncertain relevance of the rat osteosarcoma finding to humans, prescribe FORTEO® only for patients for whom the potential benefits are considered to outweigh the potential risk. FORTEO should not be prescribed for patients who are at increased baseline risk for osteosarcoma (including those with Paget's disease of bone or unexplained elevations of alkaline phosphatase, pediatric and young adult patients with open epiphyses, or prior external beam or implant radiation therapy involving the skeleton)

Forteo, the drug that was found to cause a rare, serious bone cancer (osteosarcoma) in rodents, but drug proponents suggested such cancers would not occur in humans. But this week, there have been three reported cases of this rare bone cancer developing in people taking Forteo.

The most recent case was detailed in an abstract (# SU0345) presented at the annual meeting of the American Society for Bone Mineral Research in Denver, from which I just returned. This is the third case in the recent literature. The first case of osteosarcoma associated with Forteo use was published in the Journal of Bone Mineral Research in 2007 (JBMR vol. 22, p. 334), and a second case was published on-line in Osteoporosis International on the 14th of July, 2009.
Read more...

What you can do to protect your bones-
It is a myth that calcium is the cure for prevention. The best prevention is regular weight-bearing exercise, an increased intake of vitamin D-3 (at least 2,000 IU a day, more if you live in northern latitudes and are a person of color or someone who does not go in the sun), vitamins K and C, magnesium, and a high intake of vegetables (especially leafy green and yellow vegetables). A study reported in the American Journal of Clinical Nutrition found that the best preventative against osteoporosis is a high intake of vegetables, both because of the high potassium content and the fact that a number of flavonoids in vegetables directly prevent calcium loss. In addition, avoiding a high intake of red meats is also essential.

Bone Health Testing - Better than DEXA and no radiation exposure
Bone Density Measurements: Most people think of bone density studies as involving special x-ray machines. In fact, better measurements can be obtained from blood tests. One of the best involves measurements of pyridinium crosslinks and deoxypridinoline (DPD).

Pyridinium is a substance found in both bone and cartilage and deoxypyridinoline is found predominantly in bone. High levels of DPD indicate osteoporosis when other bone disorders are not present.

Pyridinium is elevated in a number of conditions including osteoporosis, rheumatoid arthritis, osteoarthritis and chronic alcohol abuse. These tests are very valuable in following responses to treatments.

And when getting annual physicals, make sure to request a Phosphorus level so you can determine the Calcium-Phosphorus ratio. Years ago Phosphorus was removed from the metabolic panel by Medicare because they believed it to be a cost cutting measure and an unnecessary test.

You might also consider testing for vitamin D (25 OH test) and parathyroid hormone.

Thank you to Susan Brown PhD and Russell Blaylock MD for sharing some of the information in this post.

Sunday, August 16, 2009

The Dangers of Osteoporosis Drugs

UPDATE: August 25 - Feedback from a fluoride based Fosamax user whose bones seem to be crumbling before her eyes.
I am a femur-fracture survivor...bilateral. The right leg broke in March, the left one in July, 2009. I also suffered a compression fracture at L1 in May.

I was given Fosamax 10 years ago as a preventive measure. Now I am worse than I would have been 20 years down the road. I cannot begin to tell you that there are women breaking a leg everyday! And they do not know why. It was through the fact, that the orthopaedic doctor who took my emergency case on the first leg, had just received some information about the bilateral fractures. If you held my x-ray up against several other womens, you could not tell us apart!

I hope you continue to write and correspond about this important subject. My life has been taken away from me in a way that I never dreamed would happen.

COMMENT:
The news on the bisphosphonates just gets worse and worse. And incredibly, they don't work in preventing fracture most of the time. The latest US government report shows an increase in fracture rate of 55% since 1995!
Dr. Carolyn DeMarco

-----------------------------

Looks like Sally Field will have to give up flying or Boniva: Boniva now found to cause MID-FEMUR FRACTURES.

Another Big PhARMA fiasco, as all the current osteoporosis drugs seem to be.

Of course you don't hear too much about their fluoride content and how this damages the thyroid and bone health, but then how would they mask Jaw Osteonecrosis?

You may think this a bit cynical on my part, but you know when you read this kind of information day after day it becomes hard to believe that so many people are lured in to these products because of celebrity adverts.

And many physicians do not even consider the possibility that bisphosphonates could have some adverse effects on the bone.

More Reading

and

More Reading

Many articles on this topic are posted on Natural Health News which you can locate by using the search box.

Wednesday, August 12, 2009

Immune Supression for Osteoporosis?

UPDATE: August 25 - Feedback on bisphosphonate drugs which contain fluoride, crumbling bones right before your eyes.
I am a femur-fracture survivor...bilateral. The right leg broke in March, the left one in July, 2009. I also suffered a compression fracture at L1 in May.

I was given Fosamax 10 years ago as a preventive measure. Now I am worse than I would have been 20 years down the road. I cannot begin to tell you that there are women breaking a leg everyday! And they do not know why. It was through the fact, that the orthopaedic doctor who took my emergency case on the first leg, had just received some information about the bilateral fractures. If you held my x-ray up against several other womens, you could not tell us apart!

I hope you continue to write and correspond about this important subject. My life has been taken away from me in a way that I never dreamed would happen.

-----------------------------------------------------------------------

These two articles arrived this morning in the same newsletter. I thought it interesting because I had just posted on saturated fat and mentioned how it is necessary to help make Vitamin D work.

Then there's the article about Vitamin D that arrived earlier in the day. There must be a message here.

Of course this is madness to me because there is no consideration of what natural approaches might be more effective and less expensive that a drug that the FDA now is worried about it suppressing immunity.

There's weight bearing exercise, even if you have to so it sitting. And there's Vitamin K, another fat soluble vitamin. Nettle can help too because it is a very potent cytokine reducer (what the TNF drugs do) without suppressing your immune system.

This drug is very much like the Rheumatoid Arthritis drugs, RA is often connected to wheat, gluten and gliaden allergy. Perhaps a RAST test might be a better place to start.
FDA Questions Denosumab Safety in Advisory Meeting Documents
FDA staff has expressed concerns that denosumab, the investigational biologic drug for osteoporosis, may increase risk of serious infections through its activity against an important immune system modulator. The agency believes the drug --... full story http://www.medpagetoday.com/ProductAlert/Prescriptions/tb/15486

Denosumab a Winner in Phase III Osteoporosis Trials
An investigational biologic drug for osteoporosis increased bone density and reduced fractures in men and women in two placebo-controlled trials. Three years of treatment with denosumab reduced radiographic spine fractures more than two-thirds in the... full story http://www.medpagetoday.com/Endocrinology/Osteoporosis/tb/15474

Related to the issue of osteoporosis and immune suppression is this information about fluoride based antibiotics. These drugs also increase risk of tendon rupture, interfere with proper thyroid function, as well as encourage brittle and weaker bones.

Wide Use of Fluoroquinolones Raises Fear of TB Resistance
The widespread use of fluoroquinolone antibiotics may be creating strains of tuberculosis resistant to the drugs, researchers said. Patients with more than 10 days of fluoroquinolone exposure before a TB diagnosis were seven times more likely to have... full story http://www.medpagetoday.com/InfectiousDisease/Tuberculosis/tb/15477

There's also something here that might explain why mainstream medicine might not be offering you the best care.

Read a review here

Thursday, May 14, 2009

Bisphosphonates, X-Rays and Your Jaw

It amazes me that - for the most part - people who have been prescribed the bisphosphonate osteoporosis drugs have no knowledge that these drugs have serious risks.

One of the main risks is that they are based in fluoride compounds. Fluoride is known to cause this type of reaction - that is "swiss cheese" bone structure that leads to brittle and weak bones.

Now it seems that medical pundits want you to be exposed to cancer causing ionizing radiation in x-ray diagnosis of the problem of rotting jaw bone, a serious side effect of these drugs.

In order to prevent reliance on the drugs that are commonly used in medical care for osteoporosis, we have developed a protocol that is based on natural treatment and people who choose it, after we provide them with the educational material that is required, seem to do very well with getting healthier bones.

X-rays Help Predict Permanent Bone Damage From Bisphosphonates

ScienceDaily (2009-05-12) -- Bisphosphonates have been found to place people at risk for developing osteonecrosis of the jaws (a rotting of the jaw bones). Dentists, as well as oncologists, are now using X-rays to detect "ghost sockets" in patients that take these drugs and when these sockets are found, it signals that the jawbone is not healing the right way. Early detection of these ghost sockets can help the patient avoid permanent damage to their jawbone. ... > read full article

Friday, March 6, 2009

How To Keep Muscles And Joints Healthy

X-ray image of knee


In today's busy life and routine, what we often don't care
about is the health of our body. Taking care of our body is
not about just going to a doctor when we feel sick, but
taking action to prevent problems from occurring in the
future. We most often ignore our muscles and joints, and
then end up having to pay the price by spending large
amounts on surgeries or treatments we would not have needed
in the first place.

Our joints are responsible for important functions in our
body. They help in keeping the bones intact. They require
just as much care as other parts of our body like our teeth
or eyes. Our joints are the point that allows our bones to
bend flexibly. The muscles are attached to the bones with
tendons, so that as the bone moves, the muscle moves as
well. As we grow, the muscles get stronger and stronger
with exercise, enabling us to provide more energy
and power.

The most widespread problems that cause muscle or joint pain
are arthritis, muscular dystrophy, osteoporosis, repetitive
stress injuries, tendinitis, and strains. I will explain all
of these briefly, and then talk about what could be done to
prevent them.

Arthritis is when the joints become inflamed and there is
difficulty moving them. It is most common in older people,
but even children have been known to develop arthritis.
Osteoporosis causes the tissue in the bone to get weaker and
brittle thus making it easier for the bone to break. This is
most common in women and even in younger girls who reduce
their body weight to an unhealthy one. Muscular dystrophy is
inherited and causes the muscles to get weaker and break
down over time. Repetitive stress injuries are those
injuries that are caused by too much stress being placed on
one part of the body. This usually happens when the same
movements are made again and again. An example of this is
tennis elbow, which is caused by playing too much tennis or
carpal tunnel from typing on a keyboard for too long.
Strains and tendinitis can occur in all ages, and occur
usually when a muscle has been overstretched. This is most
commonly caused by not warming up properly prior to a
workout.

The best way to prevent most of these problems is to
exercise. Exercising thirty minutes every day is the
minimum, but we should aim for more. Care should be taken to
warm up and cool down after every workout to prevent any
muscle from becoming strained. It is important that we
stretch all our muscles so that our body can stay healthy
for a long time.

Another way to obtain stronger muscles is to keep body fat
levels down. Large amounts of fat make the muscles lose
their elasticity with the passage of time, and this can reduce
our resistance level and make us weaker. This mostly occurs as
we grow old, and the best precautionary measure is to watch our
weight and not let ourselves become overweight. Increasing blood
circulation is another way in which we can keep our muscles healthy,
as blood flow helps the muscles.

Having a balanced diet that includes all the basic vitamins
and nutrients is another way to prevent our joints and
muscles from troubling us. Taking in a minimum of three
servings of dairy products provides the body with adequate
calcium to help rebuild the bones and prevents osteoporosis.


Make sure you watch your health now, so that you can prevent
problems and stay healthy as you get older.

Wednesday, February 18, 2009

Overlooked Health Consequences

UPDATE: 9 March 2010

Virus infections may be contributing factor in onset of gluten intolerance

ScienceDaily (2010-03-07) -- Recent research findings indicate a possible connection between virus infections, the immune system and the onset of gluten intolerance, also known as celiac disease. ... > read full article

UPDATE: 18 February
Shingles is readily treated and resolved with herbal compounds. Historically Black Walnut tincture was used to apply externally to the patches, although I have found that Valerian root tincture can be effective. Valerian may be taken inernally to help with the pain, and St. John's Wort, an effective anti-vital herbal tincture, may be used alone or in combination with Valerain for pain and help fighting the virus.
Flower essence of Impatiens can be an adjuct treatment, as in the original development of Bach's remedies he found in his hospital provings that Impatiens essence was as effective as morphine, yet it had no untoward effects.
Shingles 'risk' of arthritis drug
Some popular treatments for rheumatoid arthritis could increase the risk of the painful condition shingles, a German study suggests.

Anti-TNF (anti-tumour necrosis factor alpha) therapy drugs can slow the progress of disease and help to reduce some of the worst symptoms.

But some of them may make patients more vulnerable to shingles, a skin disease which produces sore, itchy blisters.

Writing in JAMA, the authors advised patients on such drugs be monitored.

The team at the Rheumatism Research Centre in Berlin analysed data from more than 5,000 patients on different forms of treatment.

There were 86 outbreaks of shingles - triggered by the virus Herpes zoster - among 82 patients. Thirty-nine of these coincided with treatment with the anti-TNF drugs adalimumab and infliximab.

Etanercept, a protein therapy, and conventional disease-modifying anti-rheumatic drugs were associated with 23 and 24 cases respectively.

Watchful eye

After adjusting for the age of the patient, the severity of their illness and their use of steroid hormone therapies, researchers found that the risk for patients on the anti-TNF programme almost doubled.
“ All drugs which damp down the immune response run the risk of increased risk of infection ”
Professor Alan Silman
Arthritis Research Campaign
Although this was beneath the threshold of clinical significance, which would be an increase of more than double, the researchers, led by Dr Anja Strangfeld, said their findings suggested doctors should be on the look out for shingles in the patients they treat with these drugs.

"Based on our data, we recommend careful monitoring of patients treated with monoclonal anti-TNF-alpha antibodies for early signs and symptoms of Herpes zoster," they wrote in the Journal of the American Medical Association.

Shingles is the reactivation of the virus infection that causes chickenpox. After a person has had the infection, usually as a child, the virus remains in their body and can return, usually after the age of 50.

It often first manifests as pain, itching or tingling in an area of skin on one side of the body or face before developing into a rash. Many continue to suffer chronic nerve pain once the rash has subsided.

A weakened immune system is thought to be one of the triggers, and it is suggested that this may be why anti-TNF drugs could have this effect.

"All drugs which damp down the immune response run the risk of increased risk of infection; steroids being a well known example," said Professor Alan Silman, medical director of the Arthritis Research Campaign.

"Shingles is also a rare but well recognised complication of immune drugs used to treat both autoimmune disorders such as rheumatoid arthritis as well as cancers. This distressing but fortunately treatable infection is likely to be increased in incidence in anti-TNF treated patients."
Story from BBC NEWS:http://news.bbc.co.uk/go/pr/fr/-/2/hi/health/7895202.stm
Published: 2009/02/18 © BBC MMIX
I have known for decades the benefits of cod liver oil for arthritis. Seems funny that it has taken so long to reach the hallowed halls of the BBC.
Cod oil 'cuts arthritis drug use'
A daily dose of cod liver oil can cut painkiller use in patients with rheumatoid arthritis, a study suggests.
Taking 10g of cod liver oil a day reduced the need for non-steroidal anti-inflammatory drugs (NSAIDs) by 30%, Dundee University researchers say.

Concerns about side-effects of NSAIDs has prompted research into alternative.

Rheumatologists said the study, in Rheumatology journal, funded by Seven Seas, was small but showed fish oil could benefit some patients.

Patients in the trial were either given cod liver oil or placebo and after 12 weeks asked to gradually reduce their use of NSAIDs, such as ibuprofen.

“ Anything that can help to reduce NSAID use is going to be safer for patients ”
Dr Andrew Bamji, British Society for Rheumatology
Almost 60 patients completed the nine-month trial which found 39% taking cod liver oil reduced their daily dose of NSAIDs compared with 10% taking a placebo.

The reduction in drug use was not associated with any worsening of pain or the disease, the researchers reported.

The research team at the University of Dundee, aided by colleagues at the University of Edinburgh, have now completed three studies which have all shown patients are able to cut down their NSAID use when taking cod liver oil.

It is thought fatty acids in the fish oil have anti-inflammatory properties.

Side-effects

Some side-effects of NSAIDs, such as an increased risk of stomach bleeding have been known for a long time.

But more recently, concerns have been raised about an apparent increased risk of heart attacks and strokes in those taking the drugs.

Study leader Professor Jill Belch said the study offered hope to many rheumatoid arthritis patients who wanted to reduce the amount of pain medication they take.

"Every change in medication should be discussed with a GP but I would advise people to give cod liver oil a try for 12 weeks alongside their NSAIDs and then try to cut it down if they can manage it but if they don't manage it, that's fine.

"If you can get off NSAIDs it will be much safer."

National Rheumatoid Arthritis Society chief executive Ailsa Bosworth said: "People with rheumatoid arthritis still rely heavily on NSAIDs, even though the safety of these drugs is under scrutiny.

"We look forward to more research in this area."

British Society for Rheumatology president Dr Andrew Bamji said it was a small study so difficult to draw firm conclusions.

But he added: "Anything that can help to reduce NSAID use is going to be safer for patients.

"It does look as if the results are positive and that is quite interesting.

"I would say to patients by all means take cod liver oil and when you feel ready start to reduce your NSAID dose."

But he stressed that patients must discuss plans with their doctor because it was important that physicians were aware of all medications and supplements the patient was taking.

Story from BBC NEWS:http://news.bbc.co.uk/go/pr/fr/-/2/hi/health/7307298.stm
Published: 2008/03/25 © BBC MMIX
Originally posted 20 January
TV adverts make me angry.

One reason is because I do not think these ads should be on TV. Secondly I think the ads are disease mongering and an effort to increase profits for Big Pharma.

One new ad I saw the other day while flipping channels, since I am not a TV addict or fan, was an ad for Humira in the treatment of psoriasis.

Notwithstanding, Humira is used as a treatment for rheumatoid arthritis and other so described "auto-immune" disorders.

Humira(adalimumab) is a recombinant human IgG1 monoclonal antibody specific for human tumor necrosis factor (TNF). This means it is a genetically modified product, that in itself creates a plethora of problems.

Humira has a Black Box warning for the risk of tuberculosis. Other serious sided effects may include serious infections, neurologic reactions and malignancies. More information may be found in the professional section at RxList.com.

I'm in the midst of writing the January issue of my opt-in newsletter, herbalYODA Says! The topic happens to be detoxification and as part of my research I came across an interesting piece of information about non-Celiac gluten sensitivity.

I happen to be someone with gluten and gliaden sensitivity. I have many other food allergies which I attribute to certain situations I experienced in the last couple of decades which took a pretty devastating toll on my adrenals.

I'd say there were some other factors because my father had psoriasis. It isn't something I have but I have helped many people who lived with this condition, from mild to severe, to resolve their case.

This of course alerts me to the fact that I probably should not ever have had bread. It also has to do with heritage and the metabolic typing as developed by William D. Kelley, DDS.

Simply what this means is that there are certain symptoms of gluten and gliaden intolerance, even if you do not have Crohn's.

Conditions Often Associated With Gluten Sensitivity
From 'Going Against the Grain' (Chicago, IL: Contemporary Books, 2002) by Melissa Diane Smith

Autism
Autoimmune diseases
Chronic neurological conditions of unknown cause
Dermatitis herpetiformis (a blistery, itchy skin disease)
Downs syndrome
Epilepsy and/or a personal history of migraine headaches, hyperactivity and/or digestive problems
Frequent unexplained headaches
Osteoporosis and other bone diseases unresponsive to conventional treatment
Infertility and pregnancies of poor outcome
Insulin-dependent (type I) diabetes
Intestinal lymphoma or esophageal cancer
Psoriasis
Schizophrenia
Sjogren’s disease (dry-eye, dry-skin syndrome)

I find it interesting that Sjogren's is on this list along with psoriaisis, as Humira is often prescribed for Sjrogren's as well.

I noted in some other data that esophageal cancer is related to gluten intolerance (wheat allergy) and the articles I found on this date back to the 1970s.

This is the long way around but if you have any of these health issues perhaps you want to demand your doctor to order some food allergy testing, and re-consider Humira.

Or at least ask why your health care provider missed this one.

If your doctor looks at you like you are crazy then refer them to this study -
The innate immune system is an old system (evolutionarily speaking) that predates the antibody-producing “adaptive immune system” and nonspecifically defends against pathogens.

Biopsies from 5 out of 6 patients showed an IL-15 response to at least one gliadin fragment. The implication is that the majority of people have an immune response to wheat, even if they don’t have Celiac disease. The reason they aren’t diagnosed as Celiac patients is they don’t have circulating anti-gliadin antibodies (and they presumably don’t yet have severe structural damage to their intestinal tract as judged by biopsy or endoscopy), but as the paper shows, people can react to gluten without producing antibodies via the innate immune system.

This is the first time that an IL-15-mediated innate response to gliadin is described in individuals without celiac disease. The authors of the study believe that “gluten elicits its harmful effect, throughout an IL-15 innate immune system response on all the individuals. This innate response is found in both patients with and without celiac disease.” However, in patients with celiac disease, an adaptive response to gluten also takes place.

Study reference: Bernardo D, Garrote JA, Fernandez-Salazar L, et al. Is gliadin really safe for non-coeliac individuals? Production of interleukin 15 in biopsy culture from non-coeliac individuals with gliadin peptides. Gut, 2007;56:889-890.

Six people in the study had symptoms including gastroesophageal reflux disease (GERD), hiatal hernia, colic, abdominal pain, diarrhea and chronic gastritis. How many people have these conditions and take medications for them instead of considering that the bread, pasta and other wheat products they are eating may be the culprit behind their problems?
or have them look up the work of Kenneth Fine, MD or Alessio Fasano, M.D.

There is just more here than meets the eye - "Many gluten-sensitive make the mistake of substituting too many non-gluten grains (rice, corn, millet, buckwheat, quinoa, amaranth and teff) and sugars in place of gluten grains. This can lead to carbohydrate sensitivity and conditions such as Syndrome X and type II diabetes. To prevent the development of a new health problem, emphasize vegetables, such as salad greens, broccoli, green beans and asparagus, in place of gluten grains."

If you are interested in food allergy testing, the same system I used to uncover mine, please contact us.

By the way, one of my original teachers in natural healing always taught that RA and gluten allergy go hand-in-hand.

Certainly altering your nutrition and food plan first can do a lot before you succumb to another dangerous drug, and it just might heal your condition.