Antioxidants aid arterial health

Who needs Liptor when antioxidant vitamins and minerals, good nutrition, and other health promoting activities like exercise keep your innards healthy while improving cardiovascular health -- better blood sugar and better cholesterol profiles.?

HOLON, Israel, July 7 (UPI) -- Vitamin C, vitamin E, co-enzyme Q10 and selenium supplement had beneficial effects for those with cardiovascular risk factors, researchers in Israel said.
Reuven Zimlichman and colleagues at the Wolfson Medical Center in Israel said the study involved 70 patients from the center's hypertension clinic.
"Antioxidant supplementation significantly increased large and small artery elasticity in patients with multiple cardiovascular risk factors," Zimlichman said in a statement. "This beneficial vascular effect was associated with an improvement in glucose and lipid metabolism as well as significant decrease in blood pressure."
The research team randomized the 70 patients to receive either antioxidants or placebo capsules for six months.
The study, published in the journal Nutrition  Metabolism, found that at the three-month and six-month mark, patients in the antioxidant group had more elastic arteries -- a measure of cardiovascular health -- better blood sugar and better cholesterol profiles.

Aloe Vera, Not Dangerous Drugs

Shawn M. Talbot, PhD, author of A Guide to Understanding Dietary Supplements, the aloe plant also “has been shown to exert beneficial effects on cardiac disease risk factors by reducing blood levels of cholesterol, triglycerides, and glucose.”

Learn more about Aloe

Read more about Aloe 

Triglycerides: The Real Fat That Can Kill You

New blood fat heart disease
I am not sure where medicine or these alleged researchers have been burying their heads in the sand but I've known about the impact of triglycerides for a hell of a long time.

I've also known that the problem with the rapid rise in cardiovascular dis-ease began rising in the mid to late 1950s when the dairy industry began homogenizing milk.

The problem with homogenization is that the fat globules become so small that they flow by osmosis through the digestive system directly into the blood stream.

Now they want to make you believe that this is a "new" blood fat. And yes it is different than cholesterol, which generally is not known to kill you.

Since I've known about this from college studies in medicine and nutrition, about 45 years has whistled by.

Things must be pretty dusty in the brains of mainstream medicine.

New blood fat heart disease link
A type of blood fat different from cholesterol may play a key role in heart disease, a study suggests.
Cambridge University researchers looked at the role of triglycerides, which is produced in the liver and derived from foods such as meat and dairy products.
The analysis of 350,000 people from 101 previous studies found those with higher levels of the blood fat were more likely to have heart disease.
But experts warned more research was needed to confirm the link.

The analysis centred on a specific gene which is known to influence the levels of triglycerides, the Lancet medical journal reported.

“ It could yet prove to be an important step towards tackling cardiovascular disease but we mustn't get ahead of ourselves ”
Mike Knapton, British Heart Foundation

Previous research has looked into the issue, but has been inconclusive.
But the latest study found those with the variation in the gene which boosted triglyceride levels had an 18% greater risk of heart disease than those that did not.
Lead researcher Dr Nadeem Sarwar said the findings suggested the blood fat could be causing heart disease in some way.
But he added further research involving the lowering of the levels of the blood fat was now needed to confirm the suspicion.
"Such trials should help establish whether lowering triglyceride levels can reduce the risk of heart disease."
Mike Knapton, of the British Heart Foundation, said: "It could yet prove to be an important step towards tackling cardiovascular disease but we mustn't get ahead of ourselves.
"There still needs to be larger trials before we can know whether lowering triglyceride levels can reduce heart disease risks.
"For now, people should continue to follow advice on diet, exercise, stopping smoking and medication which are still the best ways to tackle your heart disease risk."
Dr Sonia Anand, of Canada's McMaster University, agreed.
"The true nature of triglycerides effect on coronary risk still needs further clarification."

Story from BBC NEWS: http://news.bbc.co.uk/go/pr/fr/-/2/hi/health/8664917.stm
Published: 2010/05/06 © BBC MMX

Taking Too Many Pills

There is a recent TV commercial for Crestor that has a woman explaining about how her doctor put her on the drug to help her reduce LDL, or what is marketed as " bad cholesterol".

When I hear this commercial I want to have equal time to explain something very important to doctors and to women.   Since I don't have the gazillions of disposable income that the PhRMA companies have, I don't have a snowflake's chance in hell of this, so I'll address it here.

One of the most problematic health issues today is thyroid function.  Part of the problem is that it is not only overlooked as important in today's Big Insurance+Big PhRMA controlled medical care, but it is also porrly diagnosed.

Yes, folks, the TSH test won't tell you " squat" !

What also is missing is that thyroid dysfunction cause your cholesterol level to rise.

Since this concept is basic physiology why is your doctor pushing a drug on you to lower cholesterol when properly evaluating thyroid function is a much better place to start?

This is also very much related to gall bladder function which can be resolved without "cutting it out" !

Another generally overlooked is the vital part sound nutrition plays in the prevention and treatment of disease, yet mainstream media continues to ignore this vital concept.

Recently, the New York Times also looked at the issue of pushing pills, especially as the vultures from PhRMA and the buzzards from Big Insurance begin their efforts to round you up for the kill, following the passing of the so-called "health" bill. (Just recall that HillaryCare wanted everyone to be taking Prozac, and we know what a disaster the SSRI drugs have become.)

Risks Seen in Cholesterol Drug Use - "With the government’s blessing, a drug giant is about to expand the market for its blockbuster cholesterol medication Crestor to a new category of customers: as a preventive measure for millions of people who do not have cholesterol problems."
http://www.nytimes.com/2010/03/31/business/31statins.html?partner=rss&emc=rss

And so did the London Daily Mail

D. Mail 29.3.10 "A NATION OF PILL-POPPERS"
Dept of Health data reveals we each pick up more than 16 prescriptions a year on average, twice as many as 20 years ago. The boom is partly put down to a profit-hungry pharma industry inventing & exaggerating ailments & then blitzing doctors to boost sales. The NHS spent £22million a DAY on prescription drugs in England in 06 - a 60% rise in real terms on 10 years earlier.
-
(A colleague's comment: Prof. Michael Oliver, emeritus professor of Cardiology at Edinburgh University, wrote in the British Medical Journal in March last year that healthy older people are being turned into patients by GPs who are too quick to prescribe pills for high blood pressure, cholesterol & mild diabetes. The standard for these is based on much younger people's needs. The professor stated that few older people are allowed to enjoy being healthy as a bureaucractic demand for documentation can lead to over-diagnosis, over-treatment & unnecessary anxiety - known as "the medication of health." GPs are pressurised by the government to hit targets & this has overtaken personal advice from GPs. Incentives known as "Quality & Outcomes Framework" mean a proportion of GP practice-income is dependent on hitting targets. He questions whether patients are warned about medications' side-effects & whether older people could be allowed to return to their previous unencumbered & reasonably fit lives.

Please note that our organization offers an excellent thyroid testing kit, and health and nutrition counseling,
http://leaflady.org/detect.html

Why Omega-3 Fatty Acids Are Essential For Your Heart

By Peter Bertonich

Recently I've written a lot about the health benefits of
taking fish oil supplements, or what is also known as Omega
3 supplements. Lets look today at the heart benefits of fish
oil supplements.

The Jan/Feb issue of Sports Health, A Multidisciplinary
Approach, has published the results of a new study.
It was a study of the heart benefits of taking fish oil
supplements, or essential fatty acid supplements, the main
component of which is fish oil.

There were 36 pro football players who took part and they
took either omega 3 fish oil supplements or else a placebo.
The fish oil capsules they took contained 2560 mg of omega-3
fatty acids (650 mg EPA and 450 mg DHA in each capsule.)

The study, or it's results, backed up the conclusions of so
many other studies that supported the health benefits of
Omega 3 fish oil supplementation that increased the levels
of essential fatty acids in the diet.

The results were good. HDL levels (good cholesterol) went up
while LDL (bad cholesterol) went down.

And triglycerides went down too, an excellent result.

Now this isn't the first fish oil supplements study to
confirm a link between improved heart health and the intake
of more fish oil, or Omega 3 fatty acids. There's now many
studies that confirm the heart benefits of fish oil
supplements.

And the American Heart Association also recommends that we
all take at least a gram a day of EPA and DHA and that if we
have elevated triglycerides that this be increased.

So now that you know how important taking sufficient Omega 3
fats in your diet is, how do you increase your intake? By
using the very best Omega 3 fish oil supplements.

Be aware that not all Omega 3 supplements are created equal.
There are issues with both the quantity of DHA in each
capsule as well as the purity of the fish oil, some fish
oils being contaminated with heavy metals and PCBs and
mercury. These are only small amounts but the best fish oil
capsules contain higher levels of DHA than most others and
undetectable levels of contaminants.

So anyone at risk of heart related health problems should be
taking the very best fish oil supplements. That's you.


Want to know more about the benefits of
(http://healthyomega3.com/) Omega 3 Fatty Acids? Or about
how to get more
(http://healthyomega3.com/heart-benefits-of-fish-oil-supplements/)
Benefits of Fish Oil in your diet? Visit Peter's Website
Healthy Omega 3 Fish Oil.

LDL Cholesterol - The Heart's No.1 Enemy

By Ned Dagostino

Cholesterol is a vital element for our health and
well-being. There are two basic types of cholesterol: HDL
cholesterol is good for our health, LDL cholesterol is bad
for our health.

The LDL cholesterol and HDL cholesterol levels are
maintained within a normal range by the body's natural
regulatory mechanism. Sometimes this regulatory mechanism
malfunctions, or maybe the body is flooded with cholesterol
by ingestion. In any case the blood cholesterol level
exceeds the normal range. This leads to a serious condition
which can lead to severe health problems.

LDL means 'fatty proteins of low density'. This in turn
means that LDL cholesterol tends to be loose and thick. LDL
cholesterol circulates with the blood and sticks to the
inner walls of the blood vessels, forming plaque and
gradually reducing the vascular passage. This condition is
called arteriosclerosis which results in atherosclerosis,
meaning degeneration of the blood vessels.

Blood backs up from this point leading to high blood
pressure which severely stresses the heart. Worse, small
bits of the LDL cholesterol blockage can get dislodged and
flow down with the blood. If these bits of LDL cholesterol
enter a capillary, which is a very fine blood vessel, the
capillary gets blocked starving the areas served by the
capillary network of vital blood. If this happens in the
brain, then areas of the brain just shut down leading to a
form of paralysis called a 'stroke'. If the blood flow to
the heart itself is cut off, a heart attack occurs possibly
leading to a fatality. These are just two situations which
can occur when LDL cholesterol exceeds the normal limit.
There are a great number of similar situations, collectively
called cardiovascular disease, which are directly linked to
the excessive LDL cholesterol level.

Heart disease can be prevented, or the risk of getting it
can be reduced, if we follow some very simple health
guidelines. The first is to counterattack the invasion of
LDL cholesterol into the body. LDL cholesterol gains entry
into the body with the food we eat. So you should mount a
watch on the kind of food you eat. Saturated fats are heavy
with LDL cholesterol and must be shunned. You can and should
include the healthy fats into your diet (e.g. omega-3 fats
found in fish) because they actively help to reduce the bad
LDL cholesterol. lots of water helps the circulatory and
excretory functions of the body, which at once improves
health and eliminates the bad LDL cholesterol.

Change your cooking medium from heavy saturated fats to
unsaturated fats and oils. Virgin olive oil is good for your
heart. These dietary changes will be very beneficial in your
battle against heart disease.

Cigarette smoking is bad for health. It harms the body in
more than just one way. Smoking increases the level of LDL
cholesterol. So quit now and your LDL cholesterol will be
gone tomorrow! The steps outlined in this article are very
easy to implement. You will avoid the risk of heart disease
if you follow them.

Medical research shows that stress leads to LDL cholesterol
buildup. Lowering your stress level will lower your blood
LDL cholesterol too. The moral of the lesson is that you
should relax more often, give up those activities that add
to your stress, and pick up those activities that reduce
your stress.

To sum up, LDL cholesterol can be controlled by eating foods
which are free of saturated fats, exercising, quitting
smoking and ridding yourself of stress. The worst thing you
can do is to panic about high LDL cholesterol levels. This
article is meant to educate you about the cause and
prevention of heart disease, not scare you. Use what you
have learnt in this article to control the LDL cholesterol
situation. Once that is under control, you can say that the
risk of heart disease is under control.

So, have you had your cholesterol tested lately?

To read more about
(http://www.reduce-high-cholesterol.com/Reduce_Cholesterol.html)
how to reduce cholesterol go to
http://www.reduce-high-cholesterol.com. You'll also find out how an
easy
(http://www.reduce-high-cholesterol.com/Cholesterol_Test.html)
over the counter cholesterol test can help you keep an eye
on your levels and decrease the number of costly trips to
the physician.

High Blood Pressure - Does Race Play a Part?

There are many different things that can put you at a greater risk for high blood pressure. If there is something in your life that makes it hard for your heart to work the way that it should, you are going to experience high blood pressure, even if you are doing some things in a healthy way. However, one of the things that has long been felt by many in the medical community to be a factor in high blood pressure is your race. It has long been thought that there are some genetic factors that make one race more apt to have high blood pressure than another. While this might be true, there are certain things that you should try and do for yourself no matter what race you are.

First of all, a big part of high blood pressure is the foods that we eat. If you come from a racial background that richly celebrates every occasion with meals that are high in fat and cholesterol, your entire family is going to see that they might have problems with high blood pressure. This might be something that is linked to race, because different races celebrate things in different ways, and the traditional cooking is much different from place to place, as well as from race to race. If you belong to a culture that has a tendency to eat foods often that are high in fat, you might want to consider changing the way that you cook on a day to day basis. If you still want to participate in your family functions and eat the foods that everyone else is eating, it is okay as long as this is only practiced in moderation. If you can cook for yourself every single day and eat foods that are low in fat and cholesterol, you are going to have a better chance of lowering your own high blood pressure. You can also encourage your family to use low fat substitutes when they are celebrating. Exercise plays a role as well.

Certain blood pressure conditions are prevalent with certain races. If you are black or Hispanic, make sure you keep your blood pressure in check A number of more serious health conditions can occur if high blood pressure is not addressed, so if you are at risk, monitor it carefully, eat well, and exercise often. By doing these things, you can prevent high blood pressure, no matter what race you may be.

Foods That Are Good For Your Cholesterol

We hear them preached everywhere, every time.. Eat good
cholesterol foods and reduce your figure. When it comes to
cholesterol, we all know that there are "good" ones and
"bad" ones, with HDL being the good type and LDL the bad
type. The problem is how to stick with the good one and get
rid of the bad one? It's a rather complicated subject, so
let's start..

Cholesterol is essential to human life, but high levels in
the bloodstream are associated with heart disease and
stroke. Specifically, high levels of LDL and low levels of
HDL are dangerous. LDL becomes hardened and forms plaque
that builds up in the arteries, slowing blood flow. HDL has
the ability to gather up excessive amounts of LDL and carry
it back to the liver.

We don't exactly eat HDL or LDL, it forms in the body. Some
of the foods that we eat do contain cholesterol, such as
eggs, dairy and animal fat. Plant oils and fats contain a
cholesterol-like substance called phytosterols. They help
lower blood cholesterol levels. Saturated and trans-fats
contribute to high LDL, as do simple carbohydrates, such as
sugar and white flour.

In general, good cholesterol foods are foods coming from
plants, because of the phytosterol they contain. Most animal
meats are not good when it comes to cholesterol, except fish
(especially deep sea fish) because they contain Omega-3
fats, which are found in canola oil as well.

One good plan to control LDL levels is including a lot of
vegetables, fruits, whole grain foods (such as oatmeal) and
fish into your daily diet. One daily bowl of oatmeal has
been shown to reduce LDL levels.

It's a healthy decision to use olive or canola oil when you
cook or bake, rather than lard or saturated fat. It has been
determined that eating certain nuts decrease risk of heart
disease. So, eat some of them every day when you can:
hazelnuts, walnut, almonds, pecans, pistachios and peanut.
An ounce a day is recommended, provided you're not allergic
to them, of course.

Another thing you can try is replacing your coffee or soda
with green tea. Green tea has many benefits related with
health, and one of them is its LDL lowering capability. If
you can't stand the original taste of green tea, don't use
processed sugar. Use honey or raw cane sugar instead.

Try taking lots of different antioxidants in your daily
diet. When cholesterol in your body becomes oxidized, they
form hard plaques in the arteries, which are very dangerous.
Antioxidants such as green tea, vegetables and fruits help
preventing this process from happening.

If you have to eat meat or poultry, make them lean cuts.
When you have to take dairy products, make sure to choose
reduced fat products made with skim or low-fat milk.

All in all, it's not difficult at all to switch from your
regular diet to good cholesterol foods. It's just a matter
of taking the right decision on what you eat.

Become A Pro In Shrimp Dishes!

Shrimps are no longer considered as a dish reserved for the
special occasion only. Now in almost every home it is cooked
regularly. The reason behind its popularity is not only the
fact that it tastes good and is easy to prepare but it is
healthy as well. For instance, less than 85 calories are
gained with 3-ounces of shrimps. Although it is known to
contain high dietary cholesterol, it doesn't increase blood
cholesterol.

Easy shrimps recipes are widely available that can help you
in preparing a shrimp dish. You can easily prepare tasty and
healthy shrimps with these recipes. A perfect shrimp dish
not only depends on the recipe used but the quality and
quantity of shrimp as well. The most popular type of shrimps
in the market is white, brown and pink shrimp. You will also
find jumbo, rock and tiger shrimps.

Shrimps are available on count per pound basis in the
market. The more the number of shrimps, the smaller their
size is. It is advisable to consider pound per person when
ordering for shrimps. Also, you should buy frozen shrimps
and later defrost them. When about to prepare a shrimp dish,
make sure to thaw the shrimps in your refrigerator before
using them.

You don't need high cooking skills for cooking shrimp.
Depending on the recipe you will either be required to cook
through boiling, cooking within the recipe itself or cooking
partially in advance.

Before providing you with an easy shrimp recipe, here are few
tips that one can follow to cook perfect tasty shrimps. The
most important tip is not to let the shrimp overcook
otherwise the shrimp will dry-up and becomes rubbery. In the
boiling method, the shrimp will rise to the top of water to
signal its done. Secondly, sometimes your shrimp smells off a
little-bit. If it is still fresh from the market then simply
rub the shrimp with baking soda and let it stay in the
refrigerator for about ten minutes. Then rinse it thoroughly
and remove the soda completely. Note that if it is giving
off a strong ammonia odor then it is time for you to throw
it away and not use it. Peeling shrimp off when raw is
easier than when cooked.

Below is an easy shrimp recipe that you can follow :

Ingredients needed:
a. 3 tbsp of garlic minced
b. cup of lemon juice
c. 2 tbsp of olive oil
d. cup of parsley(freshly minced)
e. tsp of salt
f. tsp of pepper
g. 1- pounds of cooked shrimps

Place oil and garlic in skillet over medium heat until
fragrant. After this add parsley, lemon juice, pepper and
salt. Transfer to a large bowl and add shrimps. Serve when
chilled.Enjoy!

Eggs Now an Approved Food

UPDATE: 17 August, 2010 - How Hens are Confined

Eggs have always been a health promoting food, except that somewhere along the line some diet dictocrat decided they were not heart health because they contained cholesterol.

This false notion led to those egg white products loaded with food processing chemicals to enhance shelf live and preserve the products in fluoride containing polyfilm lined paper boxes.

Its a wonder all this took so long to get out in the news. Here is an earlier story from 2001 supporting eggs for health.

And another piece on the health promoting lecithin in egg yolk. Lecithin helps keep your arteries free of plaque and in good shape.

My preference is for organic, free-range brown eggs. Brown eggs have higher sulfur content and that's another health plus.

Regular eggs 'no harm to health'
Limiting egg consumption has little effect on cholesterol levels, research has confirmed.

A University of Surrey team said their work suggested most people could eat as many eggs as they wanted without damaging their health.

The researchers, who analysed several studies of egg nutrition, said the idea that eating more than three eggs a week was bad for you was still widespread.

But they said that was a misconception based on out-of-date evidence.

Writing in the British Nutrition Foundation's Nutrition Bulletin, they said eating saturated fats was far more likely to cause health problems.
Researcher Professor Bruce Griffin said eggs were actually a key part of a healthy diet, as they were particularly packed full of nutrients.

Ingrained misconception

He said: "The ingrained misconception linking egg consumption to high blood cholesterol and heart disease must be corrected.

"The amount of saturated fat in our diet exerts an effect on blood cholesterol that is several times greater than the relatively small amounts of dietary cholesterol.

"The UK public do not need to be limiting the number of eggs they eat - indeed they can be encouraged to include them in a healthy diet as they are one of nature's most nutritionally dense foods."

While elevated blood cholesterol levels increase the risk of heart disease, only around a third of the cholesterol in the body comes from the diet.

Other factors such as smoking, being overweight and physical activity can influence blood fat and cholesterol levels and heart disease risk.

The British Heart Foundation (BHF) dropped its advice to limit egg consumption to three a week in 2007 in light of new evidence.

However, research by the British Egg Information Service suggests 45% of consumers still believe it was sensible to limit consumption.

Victoria Taylor, a senior BHF dietician, said: "We recommend that eggs can be eaten as part of a balanced diet.

"There is cholesterol present in eggs but this does not usually make a great contribution to your level of blood cholesterol.

"If you need to reduce your cholesterol level it is more important that you cut down on the amount of saturated fat in your diet from foods like fatty meat, full fat dairy products and cakes, biscuits and pastries."

In 2007 the Egg Information Service was banned from re-running a television commercial from the 1950s which urged viewers to "go to work on an egg" to celebrate its 50th anniversary.

The Broadcast Advertising Clearance Centre said the slogan went against the principle of eating a varied diet.

Story from BBC NEWS:http://news.bbc.co.uk/go/pr/fr/-/2/hi/health/7882850.stm
Published: 2009/02/11 © BBC MMIX

Cholesterol Normal Range - How To Stay Healthy

If you have worked hard over the past few months to lower
your cholesterol levels, you want to ensure that you keep it
within the cholesterol normal range that is considered
acceptable. Simply put, in order to stay fit as you age, you
will want to continue to monitor your cholesterol levels,
eat a proper diet and exercise regularly.

Once you have determined which diet is helping you control
your cholesterol normal range, stick to that diet with
determination. Snacks now and then are not completely off
limit, as long as you don't indulge excessively. Your
primary problem might have been over eating the bad choice
foods. So resist the temptation of falling back into
unhealthy habits, and continue the good work.

To keep within cholesterol normal range your exercise
routine should be kept up too. Getting used to daily
exercise is not easy initially and once you start missing
your exercise sessions, you may find yourself getting back
to your old routine. So every time you feel like missing a
session, recall how hard it was to make exercise part of
your daily routine. Also, a bit like your diet, do exercises
that you will enjoy (or dislike least if you really are
averse to exercise). Check with your doctor if you are
starting exercise for the first time.

It's important to maintain a routine of good health habits.
Even though you have successfully gotten into a cholesterol
normal range for the time being, there is still the
possibility it can rise again. Remember how good it feels to
have your health and vitality back whenever you're tempted
to cheat.

If you are one of those people who find it hard to maintain
cholesterol normal range levels, consult your doctor for
some medication. Not all cholesterol levels can be lowered
easily. Sometimes medication is necessary, especially when
cholesterol is produced in excess in the body. It's also
necessary when you've had a heart problem, and when natural
ways to reduce cholesterol take too long.

Poor diet could hinder the effectiveness of any medication
you take, so make sure that you maintain a good diet along
with intake of medication to lower cholesterol. By
maintaining a cholesterol normal range, it is also good for
the heart, and keeps you fitter and younger for a longer
time. In fact, most doctors that prescribe medication will
insist that you combine a healthy lifestyle with the
medication rather than rely totally on medication.

In order to have a healthy cholesterol normal range, you
must exercise and eat only healthy cholesterol friendly
foods that you enjoy. When you balance the correct foods
with exercise you will find that you not only look better,
but feel better as well.

LDL Cholesterol And Heart Disease

Cholesterol is a substance that is found in our blood. It is
usually associated with other substances, notably the
lipoproteins named LDL and HDL. The association with HDL is
good for our health whereas the association with LDL is bad.
Let us find out how these associations actually affect our
health and how we can guard against their adverse effect on
our health.

HDL cholesterol is beneficial to the body and must be
transported to all parts of the body by the bloodstream,
whereas LDL cholesterol must be eliminated from the body via
the very same bloodstream. The body has a mechanism to
regulate the levels of LDL cholesterol and HDL cholesterol
in the blood. Bad eating and lifestyle habits cause the
cholesterol levels to exceed the normal healthy bounds thus
overloading the regulatory mechanism. If this condition
continues for a long time our health is jeopardized.

LDL cholesterol tends to stick to the inner walls of the
blood vessels it moves through. The coating reduces the
blood flow through the affected vessels. This means poor
circulation which translates to poor health. The coating may
increase to an extent where the blood vessel is severely
constricted. This condition is known as arteriosclerosis.

If this situation carries on for a long time, the blood flow
is obstructed and the blood pressure increases leading to
overloading of the heart. The plaque can accumulate to such
an extent that it completely blocks the blood vessel, or it
may get dislodged from one location and lodge itself in a
narrower blood vessel, like a capillary, creating a blockage
there. Blood supply is choked off at that point, and leads
to blood starvation in the region beyond the blockage.

If this blood starvation occurs in a critical area of the body,
as for example in the brain, then we get a crisis. The
affected area of the brain shuts down and this leads to a
'stroke' wherein the body experiences paralysis in those
areas controlled by the area of the brain which has shut
down. If the blood vessels of the heart are affected by
blockage, then we get a critical situation known as a heart
attack. All this is due to an excess of LDL cholesterol in
the blood.

The best way to recover from this situation is to help the
body to regulate the amounts of HDL and LDL cholesterol. We
can do this by changing over to a low-fat diet, free of
foods that are rich in LDL. Some fats, like the omega-3 fats
found in fish, are actually helpful in reducing LDL
cholesterol. So we should include fish in our diet. Drink a
lot of water to increase blood circulation and excretion.

Check the medium your food is cooked in. Stop using
polyunsaturated vegetable oils because they change to
trans-fats on heating, and trans-fats are harmful for
health. Use olive oil instead, because it is a good cooking
medium. Just this much is good enough to bring about a
drastic reduction of LDL cholesterol.

Smoking actually helps to elevate the LDL cholesterol level
in the blood. Give up smoking and see the LDL cholesterol
beat a hasty retreat. Follow the other steps in this article
to ensure your freedom from a dangerous heart condition.

A stressful lifestyle adds fuel to fire if you have an
excessive LDL cholesterol level. Tension adds to the high
LDL cholesterol situation, whereas a tension free lifestyle
actually goes a long way to decreasing the LDL cholesterol
level.

If you (or a near one) suffer from a high LDL cholesterol
level, don't get all stressed about it. That will be
counter-productive. You should be positive instead. You can
do a lot to bring the LDL cholesterol levels down to normal.
Start having a good, healthy and balanced diet. Increase the
amount of your activity. Start exercising, and continue to
do so regularly. Stop smoking altogether. Not only will your
bad cholesterol level get itself back to where it belongs,
but your exposure to heart attack and stroke will disappear
as well.

How To Keep Bad Cholesterol In Check

Cardio-vascular diseases top the list of major diseases the
world over. Medical experts opine that a high cholesterol
level in the bloodstream is the single major causative
factor in this group of diseases. So what causes high levels
of cholesterol in the blood, and what can you do to prevent
that from happening to you? Let's find out.

There is good cholesterol and there is bad cholesterol. The
good cholesterol is called HDL and is required for healthy
tissue growth and general health. The bad cholesterol is
called LDL and accelerates tissue degeneration, leading to
general poor health and some specifically dangerous
conditions. The body itself regulates the level of both
these types of cholesterol in the blood. You can unknowingly
work against the body in this critical function and fall
into the clutches of various real dangerous illnesses, or
you can choose to act wisely and help the body to regulate
these substances so that you are healthy naturally.

A high level of cholesterol is no disease in itself. The
actual diseases are born out of this condition. When there
is an excess of bad cholesterol in the blood, the
circulatory system gets stressed and consequently the heart
is strained. This leads to clogging of the arteries, a
condition known as atherosclerosis. That apart the heart
also begins to falter, a condition known as cardiac
arrhythmia. High blood pressure, stroke, and heart attack
are results of the condition brought on by high levels of
LDL in the blood. So keeping LDL in check will protect you
from these diseases. If you already have any of these
problems, keeping a check on LDL will reduce their severity.

The first step is dietary vigilance. Reduce those foods that
contain a dangerously high amount of cholesterol. Fatty
foods and animal products are notorious for their
cholesterol content. Such foods are oils, dairy produce,
poultry produce, and meats. Reduce your intake of sodium and
foods containing a lot of sodium because it is known to be
responsible for aggravating the cholesterol level in the
blood.

A sedentary lifestyle is equally bad news. Inactivity makes
the circulatory system sluggish, and the evacuation of LDL
is impaired. So the LDL accumulates to dangerous levels. The
American Heart Association has advised a minimum of thirty
minutes of exercise every day to keep heart disease at bay.
You are free to do it in one spell or to spread it over two,
three or more spells. Be regular in exercising. Thirty
minutes every day means thirty minutes every day, come rain
or shine! Maintain a comfortable exercise schedule. Don't get
carried away and strain yourself. Jogging, going for long
walks, cycling, and swimming are favored exercises. Make
exercise a part of your lifestyle. Be moderate, be
comfortable, be sensible!

Cigarette smoking is favored by a large number of people.
This habit is definitely injurious in general and especially
for people who suffer from elevated cholesterol levels. Even
exposure to secondary smoke can aggravate the level of bad
cholesterol in the blood. So stop smoking yourself, and
avoid frequenting places filled with cigarette smoke.

Hereditary and genetic factors may also be the prime cause
of high cholesterol levels in the blood. Sometimes it's not
what you eat that causes high cholesterol levels. It's just
the way you're built that does it! The body has natural
mechanisms to control cholesterol. If these mechanisms
break down then you're going to see high cholesterol levels
in your blood. Consult your physician and he will prescribe
appropriate medication which suits your personal
requirements.

Excessive levels of LDL in the bloodstream can have dire
consequences on your health, your lifestyle, and your
longevity. Before you are forced to make drastic changes in
your lifestyle by your doctor, it is better that you prevent
the situation from getting out of hand while you can do so
at your convenience. You may have to alter or moderate your
lifestyle a bit now. Make exercise a part of your schedule.
Go easy on fats and animal produce. Don't smoke. Choose good
health over bad health - keep those LDL levels in check!


Finally! a complete list of which foods are best to eat for
burning 38% more body fat. Discover the 110 amazing
fat fighting foods guaranteed to melt stubborn body fat =>
Fat Loss Foods

Correcting One of Those Cholesterol Myths

I notice from time to time that people are searching for information about keeping arteries clean and healthy. This may be associated with the rash of anti-cholesterol drug-dosing-on-a-rampage panic, or earnest queries.

Order lecithin granules through simply4health.org to help us continue this work.

I am not a fan of soy. It might be said that if I suggest a soy based supplement that I am ignoring my own best advice. My greatest concern about soy today are the facts that it is generally a GMO crop and it does have many negative health effects.

On the up side, a long used supplement, especially for those who have been convinced that eggs are evil, you might find some salvation in lecithin.

Lecithin is good for you in that it contains phosphatidyl choline, phosphatidyl inositol and essential fatty acids as linoleic acid in a tablespoon of granules. It also contains fish-oil-like, omega-3 linolenic acid. Any one of these substances is not found in a standard daily diet.

Choline & Inositol are essential for the breakdown of fats and cholesterol. And lecithin helps prevent arterial congestion, helps distribute body weight, increases immunity to viral infections, cleans the liver and purifies the kidneys.

Dr. Michael Sharon suggests that it "improves the condition of patients with neurological disorders such as tardive dyskinesia (a side effect of anti-psychotic drugs), Parkinson's disease and Alzheimer's disease or pre-senile dementia."

It may help with improving attention span which would certainly benefit ADD/ADHD issues.

Lecithin helps in maintaining the surface tension of cell wall membranes. Without enough lecithin, the cell wall hardens. This condition contributes to premature aging of the cells. The surface tension of the cell, maintained by lecithin is also responsible for transmitting nerve impulses and messages through or from the cell.

Udo Erasmus, PhD shares some lecithin function facts -

"Lecithin helps keep cholesterol soluble. In a food like eggs, which contain a large amount of cholesterol, it is especially important that lecithin be of high quality.

"Lecithin keeps cholesterol isolated from arterial linings, protects it from oxidation, and helps prevent and dissolve gall and kidney stones by its emulsifying action on fatty substances.

"Lecithin is necessary in our liver's detoxification functions, which keep us from slowly being poisoned by breakdown products of metabolic processes that take place in our body. Poor liver function is a common forerunner of cancer. According to some healers, cancer always involves the liver. Deficiency of either Choline or EFAs can induce cancer in experimental animals, and is likely involved in causing some human cancers.

"Lecithin increases resistance to disease by its role in our thymus gland. Here, EFAs are precursors of several prostaglandins, as well as being vital as part of the ammunition made by our immune cells to kill bacteria (fatty acid peroxides are used to produce bacteriocidal hydrogen peroxide).

"Lecithin is a phospholipid that makes up 22% of both the high density (HDL) and low density lipoprotein (LDL) cholesterol-carrying vehicles in our blood. These vehicles keep cholesterol and triglyceride fats in solution in our bloodstream and carry them to and from all parts of our body.

"Lecithin is an important part of membrane phospholipids that are involved in electric phenomena, membrane fluidity, and other functions for which EFAs are responsible.

"Finally, lecithin is an important component of bile. Its function in digestion is to break food fats into small droplets (emulsify them), to increase their surface area, speeding up the digestion of fats by enzymes."

Other helpful information about lecithin is that each serving (1 tbsp.) contains:
Choline 275 mg, Inositol 168 mg, Potassium 108 mg, Linoleic Acid (omega 6 EFA) 2,025 mg, Phosphatidylcholine 1,760 mg, Phosphatidylethanolamine 1,530 mg, Phosphatidylinositol 1,070 mg, Linolenic Acid (omega 3 EFA) 260 mg.

and Lecithin

Breaks up fats and cholesterol, Excellent for a healthy heart
Contains the Highest Phosphatide concentration available (98% or more!)
Is a Rich source of GLA (Gamma Linoleic Acid)
Helps the body utilize Vitamins A,D,E and K
Is Excellent for memory, concentration and recall
Cleanses liver and kidneys
Helps the body absorb nutrients

Lessen Chronic Inflammation
People whose diets supplied the highest average intake of choline (found in egg yolk and soybeans), and its metabolite betaine (found naturally in vegetables such as beets and spinach), have levels of inflammatory markers at least 20% lower than subjects with the lowest average intakes, report Greek researchers in the American Journal of Clinical Nutrition (Detopoulou P, Panagiotakos DB, et al.)

Compared to those whose diets contained <250 mg/day of choline, subjects whose diets supplied >310 mg of choline daily had, on average:

* 22% lower concentrations of C-reactive protein
* 26% lower concentrations of interleukin-6
* 6% lower concentrations of tumor necrosis factor alpha

Compared to those consuming <260 mg/day of betaine, subjects whose diets provided >360 mg per day of betaine had, on average:

* 10% lower concentrations of homocysteine
* 19% lower concentrations of C-reactive protein
* 12% lower concentrations of tumor necrosis factor alpha

Each of these markers of chronic inflammation has been linked to a wide range of conditions including heart disease, osteoporosis, cognitive decline and Alzheimer's, and type-2 diabetes.

In an accompanying editorial in the American Journal of Clinical Nutrition entitled, "Is there a new component of the Mediterranean diet that reduces inflammation?," Steven Zeisel from the University of North Carolina at Chapel Hill noted that choline and betaine work together in the cellular process of methylation, which is not only responsible for the removal of homocysteine, but is involved in turning off the promoter regions of genes involved in inflammation.

"Exposure to oxidative stress is a potent trigger for inflammation. Betaine is formed from choline within the mitochondria , and this oxidation contributes to mitochondrial redox status ," Zeisel continued.

"If the association between choline and betaine and inflammation can be confirmed in studies of other populations, an interesting new dietary approach may be available for reducing chronic diseases associated with inflammation," he concluded.

Recommended daily intakes of choline were set in 1998 at 550 milligrams per day for men and 425 milligrams a day for women. No RDI has been set for betaine, which, since it is a metabolite of choline, is not considered an essential nutrient.

Practical Tip: Egg yolks are the richest source of choline, followed by soybeans. Spinach, beets and whole wheat products are primary sources of betaine. (Olthof MR, van Vliet T, et al. J Nutr)

Cholesterol and Statins: Another physician reviews the Jupiter study

UPDATE: 21 April, 2010 -
Cholesterol Drugs May Lower Men's Sex Drive
Some new studies believe that low testosterone is associated with prostate cancer.
Eating your way to lower cholesterol Note that we do not support the use of plant sterols as they are mainly sourced from GMO soy and canola oil

ORIGINAL POST
In addition to the many posts (136) here on Natural Health News, there is a selection of related articles on our main website.

Statins reduce cardiovascular disease in healthy people, and why this study is a poke in the eye for the cholesterol hypothesis

By Dr John Briffa On November 10, 2008

It’s been going this way for a while: even healthy people should be on the cholesterol-reducing drugs known as statins. That, in a nutshell, is the verdict of a study published over the weekend which found that even in people deemed to be at low risk of cardiovascular disease, treatment with rosuvastatin (Crestor) at a dose of 20 mg per day almost halved the risk of ‘vascular events’ (such as heart attack, stroke, and death from these conditions) in middle-aged and elderly men and women. Overall risk of death was down too in those taking the rosuvastatin, to the tune of 20 per cent. Average length of treatment was a shade under two years.

These results look impressive, but it does need to be borne in mind that the study population were essentially healthy. And, because of this, the risk of things like heart attacks and strokes is generally low in this population. Just to put this in perspective, the risk of vascular events was 2.2 per cent in the group taking the statin, but 2.8 per cent in those on placebo. In other words, what is known as the absolute risk reduction (as opposed to the relative risk reduction) was a little over half a percent.

It is perhaps also worth reflecting on the fact that treatment with rosuvastatin was associated, compared with placebo, with a significantly increased risk of developing diabetes. Curiously, the authors of the study say this effect could “reflect the play of chance.” In other words, even though there was a statistically significant enhanced risk of diabetes in those taking the statin, it may have nothing to do with the statin, and everything to do with bad luck. Curiously, the authors are not similarly circumspect about the positive effects of statins seen in this study.

But the reason for writing about this study is not so much to put the results in this context, but more to explore what these results say about the widely accepted context that cholesterol causes cardiovascular disease. On the face of it, this study strengthens this concept. But I’m not so sure.

You see this study was done in individuals whose cholesterol levels were not deemed to be risky. Individuals had to have LDL cholesterol levels of less than 130 mg/L (3.37 mmol/L) to qualify. However, to qualify for the study individuals did have to have elevated levels of a substance known as C-reactive protein (CRP). CRP is a marker for inflammation in the body, and inflammation is believed to be a key underlying process in the development of cardiovascular conditions such as heart disease and stroke.

Significant benefits were seen individuals who had elevated CRP levels, but no other major risk factors for cardiovascular disease (and LDL cholesterol levels of 100 mg/L or less). This inevitably throws up the possibility that in this study, the benefits of rosuvastatin came, at least in part, through its ability to reduce CRP levels. CRP levels actually dropped by 37 per cent on average in this study.

Cholesterol levels dropped too (LDL levels actually halved), but as the authors point out, the clinical benefit associated with this was much larger than expected. This finding also adds weight to the idea that rosuvastatin’s benefits may have been less to do with bringing cholesterol levels down, and more to do with an anti-inflammatory and/or other actions.

Previously on this site I have cited a 2006 review of the evidence regarding the relationship between cholesterol and cardiovascular outcomes such as heart attacks and strokes [2]. Having reviewed a broad range of available evidence, the authors of this review stated that: ‘…no clinical trial subgroup analyses or valid cohort case control analyses suggesting that the degree to which LDL cholesterol responds to statin independently predicts the cardiovascular risk reduction.” In other words, there is no robust relationship between cholesterol levels and degree of risk of cardiovascular disease.

This is not the only review that has found this. In another from the same year, researchers reviewed 13 studies in which statins were used in individuals who had suffered from ‘acute coronary syndrome’ (i.e. heart attack and angina). Statin therapy was found to reduce risk of cardiovascular disease, but this was independent of LDL cholesterol reduction. The authors concluded that there is no significant evidence that reduction in LDL cholesterol level explains the clinical benefits seen with statin therapy on cardiovascular disease risk [3].

And what of studies that have assessed the relationship between CRP and cardiovascular outcomes? The lead author of the recent NEJM paper was also the lead author of a paper published in 2005 that assessed data from another large statin study (the so-called ‘PROVE-IT’ study) [4]. The study concluded: “Patients who have low CRP levels after statin therapy have better clinical outcomes than those with higher CRP levels, regardless of the resultant level of LDL cholesterol.”

From the same year, comes another study in which the relationship between LDL cholesterol and CRP levels and development of the process which narrows the coronary blood vessels in heart disease (atherosclerosis) in individuals treated with a statin. Atherosclerosis actually regressed in patients with the greatest reduction in CRP levels, but not in those with the greatest reduction in LDL cholesterol levels [5].

Another way of unpicking the role of cholesterol in health would be to go beyond statins, and look at the effectiveness of other cholesterol reducing drugs or strategies on overall risk of death. This latest study, and others (particularly in those at high risk of cardiovascular disease) found statin therapy is associated with a reduced risk of death. A review from 2005 assessing the impact of cholesterol reducing therapy on overall mortality. Here are the results:

Statins – statistically significant reduction in risk of overall mortality

Fibrates – NO statistically significant reduction in risk of overall mortality

Resins – NO statistically significant reduction in risk of overall mortality

Niacin – NO statistically significant reduction in risk of overall mortality

Diet – NO statistically significant reduction in risk of overall mortality

Some people argue that the failure of other cholesterol-reducing strategies is because they don’t reduce cholesterol enough. I suppose that’s one potential explanation. Here’s another: cholesterol reduction doesn’t have broad benefits for health.

References:

1. [1] Ridker PM, et al. Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein. New England Journal of Medicine. Epub 9th November 2008.

2. Hayward RA, et al. Narrative review: lack of evidence for recommended low-density lipoprotein treatment targets: a solvable problem. Ann Int Med 2006;145:520-530

3. Hulten E, et al. The effect of early, intensive statin therapy on acute coronary syndrome: a meta-analysis of randomized controlled trials. Archives of Internal Medicine. 2008;166:1814-1821

4. Ridker PM, et al. C-reactive protein levels and outcomes after statin therapy. New Engl J Med 2005;352:20-8.

5. Nissen SE, et al. Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. N Engl J Med 2005;352: 29-38
--------------------------------------------------------------------------------
Article printed from Dr Briffa’s Blog: http://www.drbriffa.com
URL to article: http://www.drbriffa.com/blog/2008/11/10/statins-reduce-cardiovascular-disease-in-health-people-and-why-this-study-is-a-poke-in-the-eye-for-the-cholesterol-hypothesis/
URLs in this post:
[1] Ridker PM, et al. Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein. New England Journal of Medicine. Epub 9th November 2008.: http://content.nejm.org/cgi/content/full/NEJMoa0807646

And Now for the Rest of the Story

Just this past Sunday (9 November, 2008) I posted this article on Natural Health News: Boosting Drug Sales with Studies.

I added one follow-up article earlier today, and now I am happy to give you something to think about in terms of why sound nutrition is a better option than wholesale use of drugs. Supplements certainly do edge out the pharmaceuticals in this study.

You'll also see how it is totally possible to fool a lot of the people a lot of the time -

Why treat nutritional deficiency with drugs?
(OMNS, November 13, 2008) A recent study suggested that statins might be used to avoid the effects of nutritional deficiency. Writing in the New England Journal of Medicine, the Jupiter group described a study of statin drugs in people with high C-reactive protein and low cholesterol. (1) High C-reactive protein levels are associated with inflammation and heart disease/stroke. The authors concluded that, in apparently healthy persons with elevated C-reactive protein levels, rosuvastatin (Crestor) significantly reduced the incidence of major cardiovascular events.

Their much-publicized claim, that this statin lowers the risk of heart attack by approximately one half, is technically correct though highly misleading. The reported annual incidence of coronary events was 37 people in 10,000 (controls) and 17 people in 10,000 (treated). Similar results were reported for risk of stroke. When expressed as a proportion, a 46% improvement (17/37) sounds large. However, an improvement of 20 events (37-17) in 10,000 people known to be at risk is less impressive. Such an improvement means that 500 people (10,000/20) with this increased risk would need to take the tablet daily for a year, to prevent one person suffering an event.

The paper does not explicitly report deaths. One reason for this may be that if a person on statins suffered a heart attack, that person was about three times more likely to die than a control who was not on statins.

The cost of rosuvastatin per person is approximately $1000 per year. So, treating enough people to prevent one heart attack costs $500,000 per year. Since about 70% of the heart attacks were not fatal, prevention of a single death from heart attack would cost even more, approximately $1,700,000. Giving the benefit of the doubt, we may allow for a similar reduction in stroke and say that "only" $250,000 is needed to protect one person from a stroke or heart attack. It is hardly surprising that Astra Zeneca's share price increased by $1.3 billion dollars on release of this paper and the corresponding media hype. (2)

The media suggested millions of healthy people could cut their risk of heart disease by taking statins. (3) They also claimed that statins could cut the risk of heart attack for "everyone". (4) This is inaccurate and incorrect. The study did not include normal healthy people, only a sample of a relatively small number of people, suffering from inflammation (increased C-reactive protein) - a known cause of heart disease and stroke. Out of 89,890 people considered for inclusion, 17,802 people (19.8%) met the specific criteria of poor health for the study. Widespread prescription of statins to healthy people is not supported by these findings.

The fact that statins produce a modest improvement is unsurprising, since they are known to lower inflammation, as do many nutritional supplements. It has pointed out that Crestor lowered C-reactive protein by 37%, but vitamin E lowers it (C Reactive Protein) by 32%, (5) and vitamin C by 25.3%. (6,7) These effects are similar to those of statins and would be expected to provide comparable benefits, without side effects and at a lower cost.

Crestor and other statin drugs have serious side effects. The incidence of established side-effects, such as rhabdomyolysis (0.3 per 10,000 per year), myopathy (1.1 per 10,000) and peripheral neuropathy (1.2 per 10,000 per year) seems low, (8) but may be underestimated as it takes time to establish long-term side-effects. (The depletion of coenzyme Q10 by statins is a particular concern.) The figures imply that for every ten people who avoid a cardiovascular event, at least one previously healthy person will suffer a non-trivial side effect of the statin drug.

The doctors reported a statistically significant increase (270) in diabetes in the statin group compared to the placebo group (216). Over the course of the study, this corresponds to an increased risk of approximately 61 in 10,000 people. So, the number of people on statins reported to become diabetic was greater than the number that avoided a heart attack! These people might have shorter lives and be at greater risk of heart disease in the long term.

Notably, the Jupiter study was stopped early, which the authors admit prevents assessment of how side-effects might outweigh reported benefits in the longer term. The study was to last 3-5 years and the criteria for stopping were not included in the original published design. (9) The paper claims that when the study was stopped "these [diabetic] events were not adjudicated by the end-point committee". The committee either knew about the diabetes in which case it was considered, or it did not and the committee was not doing its job properly.

The Jupiter name stands for Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin; the reader might think this "justification" sounds more like a marketing plan than a scientific endeavor. The researchers did not address the underlying cause of the inflammation and increased C-reactive protein: they simply treated the condition with drugs. In many cases, raised C-reactive protein is a result of nutritional deficiency. (10)

It is worth mentioning that several nutritional supplements inhibit inflammation and lower C-reactive protein, without causing known side effects. Deficiency in vitamins A, (11) B6, C, E, A, folate, carotenoids and lycopene, (12) and selenium (for example) is associated with raised C-reactive protein. (13,14,15) We suggest that the $250,000 cost of preventing a single cardiovascular event with rosuvastatin might be better spent funding a study of such inexpensive alternatives the deficiency of which may be the cause of the problem.

The people at risk could be encouraged to supplement their diet and restore their health without using these expensive drugs to conceal their underlying sickness.

Stick with the supplements!

References:

(1) Ridker P.M. Danielson E. Fonseca F.A.H. Genest J. Gotto A.M. Kastelein J.J.P. Koenig W. Libby P. Lorenzatti A.J. MacFadyen J.G. Nordestgaard B.G. Shepherd J. Willerson J.T. Glynn R.J. for the JUPITER Study Group (2008) Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein, NEJM, 359(21), 2195-2207.

(2) Mail Online (2008) Crestor news helps AstraZeneca market value leap by more than £1.3bn, 9:25 PM, 10th Nov.

(3) Smith R. (2008) Millions could cut heart attack risk by taking statins, study finds, telegraph.co.uk, 7:55AM GMT, 10 Nov.

(4) Hope J. (2008) The new statin drug that cuts the risk of heart attacks and strokes for EVERYONE, Daily Mail, 11th Nov.

(5) Devaraj S. Tang R. Adams-Huet B. Harris A. Seenivasan T. de Lemos J.A. Jialal I. (2007) Effect of high-dose alpha-tocopherol supplementation on biomarkers of oxidative stress and inflammation and carotid atherosclerosis in patients with coronary artery disease, Am J Clin Nutr, 86(5), 1392-1398.

(6) Block G. Jensen C.D. Dalvi T.B. Norkus E.P. Hudes M. Crawford P.B. Holland N. Fung E.B. Schumacher L. Harmatz P. (2008) Vitamin C treatment reduces elevated C-reactive protein, Free Radic Biol Med, Oct 10. [Epub]

(7) Sardi B. (2008) The Headline You Should Be Reading: Statin Drugs Don't Save Lives And May Increase Your Risk For Diabetes, Knowledge of Health Report, Nov 11.

(8) Law M. Rudnicka A.R. Statin Safety: A Systematic Review, The American Journal of Cardiology, 97(8), Suppl 1, S52-S60.

(9) Ridker P.M. JUPITER Study Group (2003) Rosuvastatin in the primary prevention of cardiovascular disease among patients with low levels of low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: rationale and design of the JUPITER trial, Circulation, 108(19), 2292-2297.

(10) Ford E.S. Liu S. Mannino D.M. Giles W.H. Smith S.J. (2003) C-reactive protein concentration and concentrations of blood vitamins, carotenoids, and selenium among United States adults, European Journal of Clinical Nutrition, 57, 1157-1163.

(11) Root M.M. Hu J. Stephenson L.S. Parker R.S. Campbell T.C. (1999) Determinants of plasma retinol concentrations of middle-aged women in rural China. Nutrition 15, 101-107.

(12) Boosalis M.G. Snowdon D.A. Tully C.L. Gross M.D. (1996): Acute phase response and plasma carotenoid concentrations in older women: findings from the nun study, Nutrition, 12, 475-478.

(13) Friso S. Jacques P.F. Wilson P.W. Rosenberg I.H. Selhub J.(2001) Low circulating vitamin B(6) is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels, Circulation, 103(23), 2788-2791.

(14) Devaraja S. Jialal I. (2000) Alpha tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients, Free Radical Biology and Medicine, 29(8), 790-792.

(15) Upritchard J.E. Sutherland W.H. Mann J.I. (2000): Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes, Diabetes Care, 23, 733-738.

Nutritional Medicine is Orthomolecular Medicine

Low Cholesterol Risks

Professionals only supplements resources that I rely on in my clinical work usually publish reports on studies of natural supplements that help health concerns.

While most hear about how high cholesterol is so bad and how many risky drugs you need, often you don't hear that low cholesterol can impair your immune function or defer review of other more risky markers. Triglycerides included.

I've educated on triglyceride issues for so long it seems funny to me that its just hitting headlines. Still its not prominent in the media to equal the risk to your health.

The real warning should be that yes, high triglycerides will kill you.

The Deadly Truth about Low Cholesterol
It’s a common misconception with fatal consequences: Many people still believe that low total cholesterol levels mean you’re not at risk for stroke, heart attack, or any of the other deadly risks that come with cardiovascular disease.

But in reality, nothing could be further from the truth—and unless you’re paying close attention to one particular group of fats called triglycerides, your heart could be a ticking time bomb, no matter how healthy your cholesterol might look.

Triglycerides are naturally manufactured and stored by both your liver and fat cells. At normal levels, they’re a crucial source of energy for your body—but start producing more than you can store, and those excess triglycerides will be dumped into your bloodstream, where they can wreak havoc on your arteries, heart, pancreas, and liver.1

Studies have shown that abnormally high triglyceride levels raise your risk of heart attack threefold—and when accompanied by low levels of high-density lipoproteins (HDL, or “good” cholesterol), your risk jumps a staggering 16 times higher. In fact, this ratio is one of the single strongest predictors of heart attack risk, even more accurate than the better-known LDL (low-density lipoprotein, or “bad” cholesterol) to HDL ratio.2 And it isn’t just your heart that suffers. Studies show that risk of stroke, obesity, diabetes, and liver disease are all linked to these dangerous fats.3-5

Keeping triglycerides in check is absolutely critical to your health—and a simple combination of omega-3 fatty acids, niacin and a supplement blend™ can make all the difference. One recent trial showed that supplementing with fish oil daily slashed triglyceride levels by 46 percent in as little as eight weeks.6 And niacin boasts nearly five decades of research demonstrating that it not only reduces triglycerides and LDL cholesterol, but also increases HDL levels by up to 29 percent.7-8

Finally, be wary of your blood sugar: Numerous clinical trials have shown that refined carbs and sugar can actually double triglyceride production.9-10 Tossing sugary sodas and boosting protein intake can help.11 So can supplementing with natural blood sugar managing agents like bitter melon, goat’s rue and quercetin.12-13A comprehensive formulas like some we use in our work contain these ingredients along with several others, including cinnamon. Clinical trials reveal that this popular spice can reduce triglycerides by 23 to 30 percent.14

References:

1. Webster’s New World Medical Dictionary, 3rd edition, William Schiel, Jr, MD, Author, 2008, Webster publishing.

2. Gaziano, JM., Hennekens, CH. Fasting triglycerides, high-density lipoprotein, and the risk of myocardial infarction. Circulation. 1997 Oct 21; 96(8):2520-5.

3. Grundy, SM., Cleeman, JI., Merz, CN., Brewer, HB, Jr., Clark, LT., Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation. 2004 Jul 13; 110(2):227-39. Review. Erratum in: Circulation. 2004 Aug 10; 110 6):763.

4. Tanne, D., Koren-Morag, N., Graff, E. Blood lipids and first-ever ischemic stroke/transient ischemic attack in the Bezafibrate Infarction Prevention (BIP) Registry: high triglycerides constitute an independent risk factor. Circulation. 2001 Dec 11; 104(24):2892-7.

5. Kadikoylu G, Yavasoglu I, Bolaman Z. Plasma exchange in severe hypertriglyceridemia, a clinical study. Transfus Apher Sci. 2006 Jun; (3):253-7.

6. Vega GL, Chandalia M, Szczepaniak LS, Grundy SM. Effects of N-3 fatty acids on hepatic triglyceride content in humans. J Investig Med. 2008 Jun; 56(5):780-5.

7. Crouse, JR. 3rd. new developments in the use of niacin for treatment of hyperlipidemia: new considerations for use of an old drug. Coron Artery Dis. 1996 Apr; 7 (4):321-6.

8. Drexel H. Nicotinic acid in the treatment of hyperlipidaemia. Fundam Clin Pharmacol. 2007 Nov;21 Suppl 2:5-6.

9. Teff, KL., Elliott, SS., Tschop, M., Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases in triglycerides in women. J Clin Endocrinol Metab. 2004 Jun;89(6):2963-72.

10. Furtado, JD., Campos, H., Appel, LJ., Miler, ER. Effects of protein, unsaturated fat, and carbohydrate intakes on plasma apolipoprotein B and VLDL and LDL containing apolipoprotein C-III: results from the OmniHeart Trial. Am J Clin Nutr. 2008 Jun;87 (6): 1623-30.

11. Parks, EJ., Skokan, LE. , Timlin., Dingfelder, CS. Dietary sugars stimulate fatty acid synthesis in adults. J. Nutr. 2008 Jun: 138 (6): 1039-46.

12. Sridhar MG, Vinayagamoorthi R, Arul Suyambunathan V, Bobby Z, Selvaraj N. Bitter gourd (Momordica charantia) improves insulin sensitivity by increasing skeletal muscle insulin-stimulated IRS-1 tyrosine phosphorylation in high-fat-fed rats. Br J Nutr. 2008 Apr;99(4):806-12.

13. Rivera L, Morón R, Sánchez M, Zarzuelo A, Galisteo M. Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese zucker rats. Obesity (Silver Spring). 2008 Sep;16(9):2081-7.

14. Anderson RA. Chromium and polyphenols from cinnamon improve insulin sensitivity. Proc Nutr Soc. 2008 Feb;67(1):48-53.

Should women who have paid for statins be given their money back?

I think Dr. John Briffa has a point of consideration here. If you follow this blog you know we are also big skeptics about the statins and are most concerned with the health problems they create and the ones they really do not help.

Again marketing seems to be the drive behind the sales of this class of drug. Yet more and more you read articles that seem to tell you that statins will fix just about everything.

You can do much more for your health without these drugs and other newer ones from the recombinant-GMO aisle.

Also remember that the majority of medical texts are written with men in mind and women's health - for the most part - seems to remain an aside.

The same pervasive thinking must be in the halls of Big Pharma as well.

Related to this topic are some of our posts on the benefits of vitamin C and vitamin E for heart health and other health concerns, while MSM muddies the water on the facts: Just Like the Cholesterol Myth.

By Dr John Briffa
October 24, 2008

Cholesterol-reducing drugs known as statins are hugely popular and highly profitable. It’s a shame, then, that they aren’t very effective. I say this because while they have been shown to reduce the risk of cardiovascular events such as heart attacks, they do not reduce the overall risk of death when essentially healthy individuals are being treated. This was the conclusion of an analysis of 8 studies which had been performed using individuals with no previous diagnosis of cardiovascular disease [1]. This analysis also revealed that for one individual to be protected from a cardiovascular event (heart attack or stroke) over a 5-year period, 67 people would need to be treated.

Other evidence analysing the effectiveness of the national treatment guidelines in the USA, Canada, the UK and New Zealand has revealed the so-called ‘number needed to treat’ (NNT) varies from 108-198 [2]. These startlingly high NNTs have caused some to question whether statins are really the wonder drugs some would have us believe them to be.

But wait, it gets worse. Because the limited ‘benefits’ of statins seems to be confined mainly to men. The research has found that even in women with diagnosed cardiovascular disease and/or history of heart attack or stroke, statins do not reduce overall risk of death. And in healthy women, they don’t reduce the risk of cardiovascular events (heart attacks and strokes) either. The crashing failure of statins in women was fully elucidated in an analysis from British GP Malcolm Kendrick in the BMJ last year [3].

The singular failure of statin drugs to help women was highlighted this week in the British Medical Journal [4]. In a news piece, our attention was brought to an analysis from a professor of law and a professor of clinical epidemiology in the USA. The paper focuses on the most widely prescribed statin of all - atorvastatin (Lipitor) [5]. It looks at the evidence for the effectiveness of this drug in treating essentially women with no history of cardiovascular disease. In line with previous evidence on statins, there was no significant benefit to be found.

But the authors of this analysis go further by questioning the fact that when Lipitor is promoted and advertised, there’s plenty of talk about the fact that it reduces the risk of heart attacks, but no mention of it’s stunning lack of success with regard in women. They accuse Lipitor’s manufacturers of a lack of candour here, and also ask questions of the Food and Drug Administration (FDA) in the USA. At a bare minimum, they say, the FDA should be using its muscle to protect people against misleading marketing. They also suggest that women who have paid out of their pockets as a result of false promises should be compensated for the money they’ve effectively wasted.

The authors conclude: Our findings indicate that each year reasonably healthy women spend billions of dollars on drugs in the hope of preventing heart attacks but that scientific evidence supporting their hope does not exist.
According to the BMJ new piece, Pfizer have responded to the article in the form of a statement, which I can’t locate on the web. In this statement, Pfizer claims that “Cardiovascular disease is a major cause of death in women as well as men and it ultimately kills as many women as men. However, onset of disease is delayed by some 10-15 years in women compared to men; thus the National Institutes for Health (NIH) ATP III guidelines define age as a risk factor in women at age 55, compared to age 45 for men. In addition, the AHA CVD Guidelines for Women were updated in 2007 and recommend that healthcare professionals should focus on women’s lifetime heart disease risk, not just short-term risk.”

Let this not distract us from the fact, I say, that statins have not been shown to benefit essentially healthy women. And let’s not forget either that for each person that benefits from taking statins, many, many others don’t.

References:

1. Abramson J, Wright JM. Are lipid-lowering guidelines evidence-based? Lancet 2007;369:168-169

2. Manuel DG, et al. Effectiveness and efficiency of different guidelines on statin treatment for preventing deaths from coronary heart disease: modeling study. BMJ 2006;332:1419

3. Kenrick M. Should women be offered cholesterol lowering drugs to prevent cardiovascular disease? No. BMJ 2007;334:983

4. Dobson R. Atorvastatin advertising misled over benefits for women, study claims. BMJ 2008;337:a2209

5. Eisenberg T, et al. Statins and Adverse Cardiovascular Events in Moderate-Risk Females: A Statistical and Legal Analysis with Implications for FDA Preemption Claims. Journal of Empirical Legal Studies. Published Online: Sep 5 2008
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Article from: http://www.drbriffa.com/blog/2008/10/24/should-women-who-have-paid-for-statins-be-given-their-money-back/